3FCL
Complex of UNG2 and a fragment-based designed inhibitor
Summary for 3FCL
Entry DOI | 10.2210/pdb3fcl/pdb |
Related | 3FCF 3FCI 3FCK |
Descriptor | Uracil-DNA glycosylase, 3-{[(4-{[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]amino}butyl)amino]methyl}benzoic acid, THIOCYANATE ION, ... (4 entities in total) |
Functional Keywords | dna repair, uracil, uracil dna glycosylase, alternative splicing, disease mutation, dna damage, glycosidase, host-virus interaction, hydrolase, mitochondrion, nucleus, phosphoprotein, transit peptide |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051 |
Total number of polymer chains | 2 |
Total formula weight | 52245.69 |
Authors | Bianchet, M.A.,Chung, S.,Parker, J.B.,Amzel, L.M.,Stivers, J.T. (deposition date: 2008-11-21, release date: 2009-04-28, Last modification date: 2023-12-27) |
Primary citation | Chung, S.,Parker, J.B.,Bianchet, M.,Amzel, L.M.,Stivers, J.T. Impact of linker strain and flexibility in the design of a fragment-based inhibitor Nat.Chem.Biol., 5:407-413, 2009 Cited by PubMed: 19396178DOI: 10.1038/nchembio.163 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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