3UFJ
Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine
Summary for 3UFJ
Entry DOI | 10.2210/pdb3ufj/pdb |
Related | 2RBA |
Descriptor | G/T mismatch-specific thymine DNA glycosylase, 5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*GP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3', 5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(UF2)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3', ... (4 entities in total) |
Functional Keywords | dna damage, dna repair, dna binding, glycosidase, nucleus, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13569 |
Total number of polymer chains | 6 |
Total formula weight | 74425.53 |
Authors | Pozharski, E.,Maiti, A.,Drohat, A.C. (deposition date: 2011-11-01, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Maiti, A.,Noon, M.S.,Mackerell, A.D.,Pozharski, E.,Drohat, A.C. Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc.Natl.Acad.Sci.USA, 109:8091-8096, 2012 Cited by PubMed: 22573813DOI: 10.1073/pnas.1201010109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.967 Å) |
Structure validation
Download full validation report