Complex of UNG2 and a fragment-based design inhibitor

Summary for 3FCK

Related3FCF 3FCI 3FCL
DescriptorUracil-DNA glycosylase, 3-({[3-({[(1E)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid (3 entities in total)
Functional Keywordsdna repair, uracil, uracil dna glycosylase, alternative splicing, disease mutation, dna damage, glycosidase, host-virus interaction, hydrolase, mitochondrion, nucleus, phosphoprotein, transit peptide
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Mitochondrion. Isoform 2: Nucleus P13051
Total number of polymer chains1
Total molecular weight25890.48
Bianchet, M.A.,Chung, S.,Parker, J.B.,Amzel, L.M.,Stivers, J.T. (deposition date: 2008-11-21, release date: 2009-04-28, Last modification date: 2017-11-01)
Primary citation
Chung, S.,Parker, J.B.,Bianchet, M.,Amzel, L.M.,Stivers, J.T.
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5:407-413, 2009
PubMed: 19396178 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.163
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225301.0%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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