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3FCK

Complex of UNG2 and a fragment-based design inhibitor

Summary for 3FCK
Entry DOI10.2210/pdb3fck/pdb
Related3FCF 3FCI 3FCL
DescriptorUracil-DNA glycosylase, 3-({[3-({[(1E)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid (3 entities in total)
Functional Keywordsdna repair, uracil, uracil dna glycosylase, alternative splicing, disease mutation, dna damage, glycosidase, host-virus interaction, hydrolase, mitochondrion, nucleus, phosphoprotein, transit peptide
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
Total number of polymer chains1
Total formula weight25890.47
Authors
Bianchet, M.A.,Chung, S.,Parker, J.B.,Amzel, L.M.,Stivers, J.T. (deposition date: 2008-11-21, release date: 2009-04-28, Last modification date: 2023-12-27)
Primary citationChung, S.,Parker, J.B.,Bianchet, M.,Amzel, L.M.,Stivers, J.T.
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5:407-413, 2009
Cited by
PubMed: 19396178
DOI: 10.1038/nchembio.163
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.64 Å)
Structure validation

217705

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