Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor

Summary for 2ZHX

DescriptorUracil-DNA glycosylase, Uracil-DNA glycosylase inhibitor (3 entities in total)
Functional Keywordsdna repair, ung-ugi complex, ung-dna interactions, dna damage, glycosidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMycobacterium tuberculosis H37Rv
Total number of polymer chains14
Total molecular weight247073.52
Kaushal, P.S.,Talawar, R.K.,Krishna, P.D.V.,Varshney, U.,Vijayan, M. (deposition date: 2008-02-11, release date: 2008-05-20, Last modification date: 2018-11-21)
Primary citation
Kaushal, P.S.,Talawar, R.K.,Krishna, P.D.V.,Varshney, U.,Vijayan, M.
Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources
Acta Crystallogr.,Sect.D, 64:551-560, 2008
PubMed: 18453691 (PDB entries with the same primary citation)
DOI: 10.1107/S090744490800512X
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25818 3.5% 7.3% 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-14