1KEE
 
 | | Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ... | | Authors: | Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M. | | Deposit date: | 2001-11-15 | | Release date: | 2001-12-21 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
J.Biol.Chem., 277, 2002
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8F41
 | | 3-methylcrotonyl-CoA carboxylase in filament, alpha-subunit centered | | Descriptor: | 3-methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit, ... | | Authors: | Hu, J.J, Lee, J.K.J, Liu, Y.T, Yu, C, Huang, L, Afasizheva, I, Afasizhev, R, Zhou, Z.H. | | Deposit date: | 2022-11-10 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase.
Structure, 31, 2023
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1ULZ
 | | Crystal structure of the biotin carboxylase subunit of pyruvate carboxylase | | Descriptor: | pyruvate carboxylase n-terminal domain | | Authors: | Kondo, S, Nakajima, Y, Sugio, S, Yong-Biao, J, Sueda, S, Kondo, H. | | Deposit date: | 2003-09-18 | | Release date: | 2004-03-09 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
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8GK8
 | | R21A Staphylococcus aureus pyruvate carboxylase | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, COENZYME A, ... | | Authors: | Laseke, A.J, St.Maurice, M. | | Deposit date: | 2023-03-17 | | Release date: | 2023-08-30 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus aureus Pyruvate Carboxylase.
Biochemistry, 62, 2023
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2DZD
 | | Crystal structure of the biotin carboxylase domain of pyruvate carboxylase | | Descriptor: | pyruvate carboxylase | | Authors: | Kondo, S, Nakajima, Y, Sugio, S, Sueda, S, Islam, M.N, Kondo, H. | | Deposit date: | 2006-09-27 | | Release date: | 2007-09-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2C00
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1T36
 | | Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ... | | Authors: | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | | Deposit date: | 2004-04-24 | | Release date: | 2004-09-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein Sci., 13, 2004
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3GID
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3G8C
 | | Crystal Structure of Biotin Carboxylase in Complex with Biotin, Bicarbonate, ADP and Mg Ion | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, BIOTIN, ... | | Authors: | Chou, C.Y, Yu, L.P, Tong, L. | | Deposit date: | 2009-02-12 | | Release date: | 2009-03-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.
J.Biol.Chem., 284, 2009
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3G8D
 | | Crystal structure of the biotin carboxylase subunit, E296A mutant, of acetyl-COA carboxylase from Escherichia coli | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, MAGNESIUM ION, ... | | Authors: | Chou, C.Y, Yu, L.P, Tong, L. | | Deposit date: | 2009-02-12 | | Release date: | 2009-03-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.
J.Biol.Chem., 284, 2009
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1W93
 | | Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae | | Descriptor: | ACETYL-COENZYME A CARBOXYLASE | | Authors: | Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L. | | Deposit date: | 2004-10-05 | | Release date: | 2005-01-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
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1W96
 | | Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A | | Descriptor: | ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A | | Authors: | Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L. | | Deposit date: | 2004-10-06 | | Release date: | 2005-01-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
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3GLK
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2GPW
 | | Crystal Structure of the Biotin Carboxylase Subunit, F363A Mutant, of Acetyl-CoA Carboxylase from Escherichia coli. | | Descriptor: | Biotin carboxylase | | Authors: | Shen, Y, Chou, C.Y, Chang, G.G, Tong, L. | | Deposit date: | 2006-04-18 | | Release date: | 2006-07-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Is dimerization required for the catalytic activity of bacterial biotin carboxylase?
Mol.Cell, 22, 2006
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1BXR
 | | STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP | | Descriptor: | CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... | | Authors: | Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. | | Deposit date: | 1998-10-08 | | Release date: | 1999-04-20 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry, 38, 1999
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1CE8
 | | CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, INOSINIC ACID, ... | | Authors: | Thoden, J.B, Raushel, F.M, Holden, H.M. | | Deposit date: | 1999-03-18 | | Release date: | 1999-07-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
J.Biol.Chem., 274, 1999
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4HR7
 | | Crystal Structure of Biotin Carboxyl Carrier Protein-Biotin Carboxylase Complex from E.coli | | Descriptor: | 1,2-ETHANEDIOL, Biotin carboxyl carrier protein of acetyl-CoA carboxylase, Biotin carboxylase, ... | | Authors: | Broussard, T.C, Kobe, M.J, Pakhomova, S, Neau, D.B, Price, A.E, Champion, T.S, Waldrop, G.L. | | Deposit date: | 2012-10-26 | | Release date: | 2013-03-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase.
Structure, 21, 2013
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1CS0
 | | Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | | Authors: | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | | Deposit date: | 1999-08-16 | | Release date: | 1999-12-10 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
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4HQ6
 | | BC domain in the presence of citrate | | Descriptor: | Acetyl-CoA carboxylase 2 | | Authors: | Heo, Y.S. | | Deposit date: | 2012-10-25 | | Release date: | 2013-10-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Insights into the Regulation of ACC2 by Citrate
Bull.Korean Chem.Soc., 34, 2013
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4HNU
 | | crystal structure of K442E mutant of S. aureus Pyruvate carboxylase | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... | | Authors: | Yu, L.P.C, Tong, L. | | Deposit date: | 2012-10-21 | | Release date: | 2013-01-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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4HNV
 | | Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Yu, L.P.C, Tong, L. | | Deposit date: | 2012-10-21 | | Release date: | 2013-01-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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4HNT
 | | crystal structure of F403A mutant of S. aureus Pyruvate carboxylase | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Yu, L.P.C, Tong, L. | | Deposit date: | 2012-10-21 | | Release date: | 2013-01-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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1DV1
 | | STRUCTURE OF BIOTIN CARBOXYLASE (APO) | | Descriptor: | BIOTIN CARBOXYLASE, PHOSPHATE ION | | Authors: | Thoden, J.B, Blanchard, C.Z, Holden, H.M, Waldrop, G.L. | | Deposit date: | 2000-01-19 | | Release date: | 2000-06-09 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Movement of the biotin carboxylase B-domain as a result of ATP binding.
J.Biol.Chem., 275, 2000
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1DV2
 | | The structure of biotin carboxylase, mutant E288K, complexed with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BIOTIN CARBOXYLASE | | Authors: | Thoden, J.B, Blanchard, C.Z, Holden, H.M, Waldrop, G.L. | | Deposit date: | 2000-01-19 | | Release date: | 2000-06-09 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Movement of the biotin carboxylase B-domain as a result of ATP binding.
J.Biol.Chem., 275, 2000
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7WTD
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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