3GID

The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) in complex with Soraphen A

Summary for 3GID

Entry DOI	10.2210/pdb3gid/pdb
Descriptor	Acetyl-CoA carboxylase 2, SORAPHEN A (3 entities in total)
Functional Keywords	atp binding, carboxylase, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, manganese, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : O00763
Total number of polymer chains	2
Total formula weight	121227.21
Authors	Price, A.,Kulathila, R. (deposition date: 2009-03-05, release date: 2009-03-17, Last modification date: 2024-02-21)
Primary citation	Raymer, B.,Kavana, M.,Price, A.,Wang, B.,Corcoran, L.,Kulathila, R.,Groarke, J.,Mann, T. Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. Bioorg.Med.Chem.Lett., 19:2804-2807, 2009 Cited by PubMed: 19359168 DOI: 10.1016/j.bmcl.2009.03.107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation