8CNT
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![BU of 8cnt by Molmil](/molmil-images/mine/8cnt) | Structure of the DEAH-box helicase Prp16 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ... | Authors: | Garbers, T.B, Neumann, P, Ficner, R. | Deposit date: | 2023-02-24 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of Prp16 in complex with ADP. Acta Crystallogr.,Sect.F, 79, 2023
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5A9J
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![BU of 5a9j by Molmil](/molmil-images/mine/5a9j) | Crystal structure of the Helicase domain of human DNA polymerase theta, apo-form | Descriptor: | DNA POLYMERASE THETA | Authors: | Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2015-07-21 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure, 23, 2015
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5A9F
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![BU of 5a9f by Molmil](/molmil-images/mine/5a9f) | Crystal structure of the Helicase domain of human DNA polymerase theta in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA POLYMERASE THETA, MAGNESIUM ION, ... | Authors: | Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2015-07-21 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure, 23, 2015
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6RM9
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![BU of 6rm9 by Molmil](/molmil-images/mine/6rm9) | Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Hamann, F, Neumann, P, Ficner, R. | Deposit date: | 2019-05-06 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
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5AGA
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![BU of 5aga by Molmil](/molmil-images/mine/5aga) | Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP | Descriptor: | CITRATE ANION, DNA POLYMERASE THETA, MAGNESIUM ION, ... | Authors: | Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2015-01-29 | Release date: | 2015-02-25 | Last modified: | 2015-12-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure, 23, 2015
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1S2M
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![BU of 1s2m by Molmil](/molmil-images/mine/1s2m) | |
6RMB
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![BU of 6rmb by Molmil](/molmil-images/mine/6rmb) | Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative mRNA splicing factor, ... | Authors: | Hamann, F, Neumann, P, Ficner, R. | Deposit date: | 2019-05-06 | Release date: | 2020-02-05 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
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6RO1
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![BU of 6ro1 by Molmil](/molmil-images/mine/6ro1) | X-ray crystal structure of the MTR4 NVL complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | Authors: | Lingaraju, M, Langer, L.M, Basquin, J, Falk, S, Conti, E. | Deposit date: | 2019-05-10 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nat Commun, 10, 2019
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6O16
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![BU of 6o16 by Molmil](/molmil-images/mine/6o16) | Crystal structure of murine DHX37 in complex with RNA | Descriptor: | DEAH (Asp-Glu-Ala-His) box polypeptide 37, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Boneberg, F, Brandmann, T, Kobel, L, van den Heuvel, J, Bargsten, K, Bammert, L, Kutay, U, Jinek, M. | Deposit date: | 2019-02-18 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.875 Å) | Cite: | Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. Rna, 25, 2019
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6O5F
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![BU of 6o5f by Molmil](/molmil-images/mine/6o5f) | Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state | Descriptor: | ATP-dependent RNA helicase DDX3X, CHLORIDE ION, RNA (5'-R(P*CP*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*GP*CP*AP*AP*GP*AP*GP*UP*GP*GP*CP*C)-3') | Authors: | Song, H, Ji, X. | Deposit date: | 2019-03-02 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.504 Å) | Cite: | The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X. Nat Commun, 10, 2019
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4KBG
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![BU of 4kbg by Molmil](/molmil-images/mine/4kbg) | |
4KBF
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![BU of 4kbf by Molmil](/molmil-images/mine/4kbf) | |
4KIT
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![BU of 4kit by Molmil](/molmil-images/mine/4kit) | Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... | Authors: | Wahl, M.C, Wandersleben, T, Santos, K.F. | Deposit date: | 2013-05-02 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.598 Å) | Cite: | Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science, 341, 2013
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5I8Q
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![BU of 5i8q by Molmil](/molmil-images/mine/5i8q) | S. cerevisiae Prp43 in complex with RNA and ADPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ... | Authors: | He, Y, Nielsen, K.H, Andersen, G.R. | Deposit date: | 2016-02-19 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA, 23, 2017
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5JPT
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![BU of 5jpt by Molmil](/molmil-images/mine/5jpt) | CRYSTAL STRUCTURE OF THE PRP43P DEAH-BOX RNA HELICASE IN COMPLEX WITH CDP | Descriptor: | ACETATE ION, CYTIDINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Robert-Paganin, J, Rety, S, Leulliot, N. | Deposit date: | 2016-05-04 | Release date: | 2017-02-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.935 Å) | Cite: | Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Nucleic Acids Res., 45, 2017
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7LIU
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![BU of 7liu by Molmil](/molmil-images/mine/7liu) | DDX3X bound to ATP analog and remodeled RNA:DNA hybrid | Descriptor: | 5'-R(*GP*GP*GP*CP*GP*GP*G)-D(P*CP*CP*CP*GP*CP*CP*C)-3', ATP-dependent RNA helicase DDX3X, MAGNESIUM ION, ... | Authors: | Enemark, E.J, Yu, S. | Deposit date: | 2021-01-27 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | DDX3X bound to ATP analog and remodeled RNA:DNA hybrid To Be Published
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5LBA
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![BU of 5lba by Molmil](/molmil-images/mine/5lba) | Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening. | Descriptor: | 1-cyclohexyl-3-[[(2~{R})-oxolan-2-yl]methyl]urea, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase Q5, ... | Authors: | Newman, J.A, Aitkenhead, H, Talon, R, Savitsky, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC) | Deposit date: | 2016-06-15 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea) To be published
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7MQJ
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![BU of 7mqj by Molmil](/molmil-images/mine/7mqj) | Dhr1 Helicase Core | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable ATP-dependent RNA helicase DHR1 | Authors: | Miller, L, Chaker-Margot, M, Klinge, S. | Deposit date: | 2021-05-05 | Release date: | 2021-09-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Nucleolar maturation of the human small subunit processome. Science, 373, 2021
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5LB3
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![BU of 5lb3 by Molmil](/molmil-images/mine/5lb3) | Crystal structure of human RECQL5 helicase in complex with ADP/Mg. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase Q5, MAGNESIUM ION, ... | Authors: | Newman, J.A, Aitkenhead, H, Savitsky, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC) | Deposit date: | 2016-06-15 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5. Nucleic Acids Res., 45, 2017
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7LUV
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![BU of 7luv by Molmil](/molmil-images/mine/7luv) | Cryo-EM structure of the yeast THO-Sub2 complex | Descriptor: | ATP-dependent RNA helicase SUB2, THO complex subunit 2, THO complex subunit HPR1, ... | Authors: | Xie, Y, Ren, Y. | Deposit date: | 2021-02-23 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife, 10, 2021
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5OOQ
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![BU of 5ooq by Molmil](/molmil-images/mine/5ooq) | Structure of the Mtr4 Nop53 Complex | Descriptor: | ATP-dependent RNA helicase DOB1, Ribosome biogenesis protein NOP53, SULFATE ION | Authors: | Falk, S, Basquin, J, Conti, E. | Deposit date: | 2017-08-08 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. RNA, 23, 2017
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5SUQ
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![BU of 5suq by Molmil](/molmil-images/mine/5suq) | Crystal structure of the THO-Sub2 complex | Descriptor: | 12-TUNGSTOPHOSPHATE, ATP-dependent RNA helicase SUB2, Tex1, ... | Authors: | Ren, Y, Blobel, G. | Deposit date: | 2016-08-03 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1. Elife, 6, 2017
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5SUP
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![BU of 5sup by Molmil](/molmil-images/mine/5sup) | Crystal structure of the Sub2-Yra1 complex in association with RNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase SUB2, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Ren, Y, Schmiege, P, Blobel, G. | Deposit date: | 2016-08-03 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1. Elife, 6, 2017
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6L5L
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![BU of 6l5l by Molmil](/molmil-images/mine/6l5l) | Crystal structure of human DEAD-box RNA helicase DDX21 at apo state | Descriptor: | MAGNESIUM ION, Nucleolar RNA helicase 2 | Authors: | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | Deposit date: | 2019-10-24 | Release date: | 2020-06-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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6L5N
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![BU of 6l5n by Molmil](/molmil-images/mine/6l5n) | Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state | Descriptor: | MAGNESIUM ION, Nucleolar RNA helicase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | Deposit date: | 2019-10-24 | Release date: | 2020-06-17 | Last modified: | 2020-08-12 | Method: | X-RAY DIFFRACTION (2.242 Å) | Cite: | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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