4K06
 
 | | Crystal structure of MTX-II from Bothrops brazili venom complexed with polyethylene glycol | | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MTX-II, ... | | Authors: | Fernandes, C.A.H, Comparetti, E.J, Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2013-04-03 | | Release date: | 2013-11-13 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom.
Biochim.Biophys.Acta, 1834, 2013
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4K09
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2WQ5
 | | Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2. | | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CALCIUM ION, PHOSPHOLIPASE A2, ... | | Authors: | Dalm, D, Palm, G.J, Hinrichs, W. | | Deposit date: | 2009-08-13 | | Release date: | 2010-03-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Non-Antibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A(2).
J.Mol.Biol., 398, 2010
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4KF3
 | | Crystal Structure of Myotoxin II (MjTX-II), a myotoxic Lys49-phospholipase A2 from Bothrops moojeni. | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog 2, ISOPROPYL ALCOHOL | | Authors: | Salvador, G.H.M, dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2013-04-26 | | Release date: | 2013-07-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like.
Toxicon, 72C, 2013
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1LN8
 | | Crystal Structure of a New Isoform of Phospholipase A2 from Naja naja sagittifera at 1.6 A Resolution | | Descriptor: | CALCIUM ION, PHOSPHATE ION, Phospholipase A2 | | Authors: | Singh, R.K, Vikram, P, Paramasivam, M, Jabeen, T, Sharma, S, Kaur, P, Srinivasan, A, Singh, T.P. | | Deposit date: | 2002-05-03 | | Release date: | 2003-05-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structure of a New Form of Phospholipase A2 from Naja naja sagittifera at 1.6 A Resolution
to be published
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3P2P
 | | ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP | | Descriptor: | CALCIUM ION, PHOSPHOLIPASE A2 | | Authors: | Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J. | | Deposit date: | 1989-11-29 | | Release date: | 1990-01-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop.
Science, 244, 1989
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1LE7
 | | CARBOXYLIC ESTER HYDROLASE, C 2 2 21 space group | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Group X Secretory Phospholipase A2 | | Authors: | Pan, Y.H, Jain, M.K, Bahnson, B.J. | | Deposit date: | 2002-04-09 | | Release date: | 2002-08-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
J.Biol.Chem., 277, 2002
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1M8T
 | | Structure of an acidic Phospholipase A2 from the venom of Ophiophagus hannah at 2.1 resolution from a hemihedrally twinned crystal form | | Descriptor: | CALCIUM ION, HEXANE-1,6-DIOL, Phospholipase a2 | | Authors: | Xu, S, Gu, L, Wang, Q, Shu, Y, Lin, Z. | | Deposit date: | 2002-07-26 | | Release date: | 2003-09-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of a king cobra phospholipase A2 determined from a hemihedrally twinned crystal.
Acta Crystallogr.,Sect.D, 59, 2003
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1M8S
 | | Crystal Structures of Cadmium-binding Acidic Phospholipase A2 from the Venom of Agkistrodon halys pallas at 1.9 Resolution (crystal grown at pH 5.9) | | Descriptor: | 1,4-BUTANEDIOL, CADMIUM ION, phospholipase a2 | | Authors: | Xu, S, Gu, L, Zhou, Y, Lin, Z. | | Deposit date: | 2002-07-25 | | Release date: | 2003-02-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of cadmium-binding acidic phospholipase A(2) from the venom of Agkistrodon halys Pallas at 1.9A resolutio
Biochem.Biophys.Res.Commun., 300, 2003
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2H8I
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2ZBH
 | | Crystal structure of the complex of phospholipase A2 with Bavachalcone from Aerva lanata at 2.6 A resolution | | Descriptor: | (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one, Phospholipase A2 VRV-PL-VIIIa | | Authors: | Kumar, S, Damodar, N.C, Jain, R, Singh, N, Sharma, S, Kaur, P, Haridas, M, Srinivasan, A, Singh, T.P. | | Deposit date: | 2007-10-20 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the complex of phospholipase A2 with Bavachalcone from Aerva lanata at 2.6 A resolution
To be Published
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1M8R
 | | Crystal Structures of Cadmium-binding Acidic Phospholipase A2 from the Venom of Agkistrodon halys pallas at 1.9 Resolution (crystal grown at pH 7.4) | | Descriptor: | 1,4-BUTANEDIOL, CADMIUM ION, phospholipase A2 | | Authors: | Xu, S, Gu, L, Zhou, Y, Lin, Z. | | Deposit date: | 2002-07-25 | | Release date: | 2003-02-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of cadmium-binding acidic phospholipase A(2) from the venom of Agkistrodon halys Pallas at 1.9A resolutio
Biochem.Biophys.Res.Commun., 300, 2003
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1MKU
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2I0U
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6AL3
 | | Lys49 PLA2 BPII derived from the venom of Protobothrops flavoviridis. | | Descriptor: | Basic phospholipase A2 BP-II, SULFATE ION | | Authors: | Matsui, T, Kamata, S, Suzuki, A, Oda-Ueda, N, Ogawa, T, Tanaka, Y. | | Deposit date: | 2018-09-05 | | Release date: | 2019-01-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | SDS-induced oligomerization of Lys49-phospholipase A2from snake venom.
Sci Rep, 9, 2019
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3R0L
 | | Crystal structure of crotoxin | | Descriptor: | ACETATE ION, CHLORIDE ION, Crotoxin chain A, ... | | Authors: | Saul, F.A, Faure, G. | | Deposit date: | 2011-03-08 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Crystal Structure of Crotoxin Reveals Key Residues Involved in the Stability and Toxicity of This Potent Heterodimeric Beta-Neurotoxin
J.Mol.Biol., 412, 2011
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6B80
 | | Crystal structure of myotoxin II from Bothrops moojeni complexed to myristic acid | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog 2, MYRISTIC ACID, ... | | Authors: | Salvador, G.H.M, dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2017-10-05 | | Release date: | 2018-10-03 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.949 Å) | | Cite: | Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
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6B81
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6B83
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2GNS
 | | Design of specific peptide inhibitors of phospholipase A2: Crystal structure of the complex formed between a group II phospholipase A2 and a designed pentapeptide Ala- Leu- Val- Tyr- Lys at 2.3 A resolution | | Descriptor: | ALVYK, Phospholipase A2 VRV-PL-VIIIa, SULFATE ION | | Authors: | Singh, N, Sharma, S, Somvanshi, R.K, Dey, S, Singh, T.P. | | Deposit date: | 2006-04-11 | | Release date: | 2006-04-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design of specific peptide inhibitors of phospholipase A2: Crystal structure of the complex formed between a group II phospholipase A2 and a designed pentapeptide Ala - Leu - Val - Tyr - Lys at 2.3 A resolution
To be Published
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2ZP5
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3Q4Y
 | | Crystal structure of group I phospholipase A2 at 2.3 A resolution in 40% ethanol revealed the critical elements of hydrophobicity of the substrate-binding site | | Descriptor: | CALCIUM ION, ETHANOL, Phospholipase A2 isoform 3 | | Authors: | Shukla, P.K, Kaushik, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | | Deposit date: | 2010-12-26 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of group I phospholipase A2 at 2.3 A resolution in 40% ethanol revealed the critical elements of hydrophobicity of the substrate-binding site
To be Published
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3QNL
 | | Crystal structure of PrTX-I complexed to Rosmarinic Acid | | Descriptor: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ISOPROPYL ALCOHOL, ... | | Authors: | dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2011-02-08 | | Release date: | 2012-02-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA(2) Inhibition.
Plos One, 6, 2011
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2ZP3
 | | Carboxylic ester hydrolase, single mutant d49n of bovine pancreatic pla2 enzyme | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Kanaujia, S.P, Sekar, K. | | Deposit date: | 2008-06-27 | | Release date: | 2008-11-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A(2)
Acta Crystallogr.,Sect.D, 64, 2008
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2ZP4
 | | Carboxylic ester hydrolase, single mutant h48n of bovine pancreatic pla2 enzyme | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Kanaujia, S.P, Sekar, K. | | Deposit date: | 2008-06-27 | | Release date: | 2008-11-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A(2)
Acta Crystallogr.,Sect.D, 64, 2008
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