2WQ5
Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2.
Summary for 2WQ5
| Entry DOI | 10.2210/pdb2wq5/pdb |
| Related | 1A3D 1A3F 1OWS 1PSH |
| Descriptor | PHOSPHOLIPASE A2, ACIDIC, CALCIUM ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | hydrolase, minocycline, phospholipase, metal-binding, lipid degradation, calcium binding loop, carboxylic ester hydrolase |
| Biological source | NAJA NAJA (INDIAN COBRA) |
| Cellular location | Secreted : P15445 |
| Total number of polymer chains | 1 |
| Total formula weight | 13949.63 |
| Authors | Dalm, D.,Palm, G.J.,Hinrichs, W. (deposition date: 2009-08-13, release date: 2010-03-23, Last modification date: 2023-12-20) |
| Primary citation | Dalm, D.,Palm, G.J.,Aleksandrov, A.,Simonson, T.,Hinrichs, W. Non-Antibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A(2). J.Mol.Biol., 398:83-, 2010 Cited by PubMed: 20211188DOI: 10.1016/J.JMB.2010.02.049 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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