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2WQ5

Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004623molecular_functionphospholipase A2 activity
A0005509molecular_functioncalcium ion binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
A0050482biological_processarachidonate secretion
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1001
ChainResidue
AASP39
AASP39
AASP39
AHOH2064
AHOH2064
AHOH2064

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1002
ChainResidue
ATYR69
AHOH2161
AHOH2162
AHOH2163
AHOH2164
AGLN4
AASN7
ATRP61

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE MIY A 1120
ChainResidue
ALEU2
ALEU2
ATYR3
ATRP18
ATRP18
AALA22
AGLY29
AARG30
APHE64
AHOH2165
AHOH2165
AHOH2165
AHOH2166
AHOH2166
AHOH2166
AHOH2167
AHOH2167

Functional Information from PROSITE/UniProt
site_idPS00118
Number of Residues8
DetailsPA2_HIS Phospholipase A2 histidine active site. CCQvHDnC
ChainResidueDetails
ACYS43-CYS50

site_idPS00119
Number of Residues11
DetailsPA2_ASP Phospholipase A2 aspartic acid active site. VCDCDRLAaIC
ChainResidueDetails
AVAL89-CYS99

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"8419939","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8419939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PSH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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