2WQ5
Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHOLIPASE A2, ACIDIC | polymer | 119 | 13356.0 | 1 | UniProt (P15445) Pfam (PF00068) | NAJA NAJA (INDIAN COBRA) | PHOSPHOLIPASE A2, PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE |
| 2 | B (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE | non-polymer | 457.5 | 1 | Chemie (MIY) | |||
| 5 | E (A) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 1 - 119 (UniProt: P15445)
| PDB | External Database | Details |
|---|---|---|
| Lys 59 | Gly 59 | conflict |
| Phe 63 | Tyr 63 | conflict |
| Lys 70 | Glu 70 | conflict |
| Gly 81 | Asp 81 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13356.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 593.6 | |
| All* | Total formula weight | 13949.6 |
