PDB: 595 resultsInfo pagesStatus searchChemie searchBIRD

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3C7I	X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide Authors: Benfield, A.P, Martin, S.F. Deposit date: 2008-02-07 Release date: 2008-08-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118, 2006
3EAC	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. Descriptor: Tyrosine-protein kinase CSK Authors: Liu, D, Seidel, R.D, Cowburn, D. Deposit date: 2008-08-25 Release date: 2009-11-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
8CZ9	Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide Descriptor: CHLORIDE ION, JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2022-05-24 Release date: 2023-05-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity. J.Exp.Med., 221, 2024
3HCK	NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures Descriptor: HCK SH2 Authors: Zhang, W, Smithgall, T.E, Gmeiner, W.H. Deposit date: 1997-03-31 Release date: 1997-10-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. FEBS Lett., 406, 1997
2RSY	Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp Descriptor: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK Authors: Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. Deposit date: 2012-09-10 Release date: 2013-04-10 Last modified: 2019-12-25 Method: SOLUTION NMR Cite: Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. J.Biol.Chem., 288, 2013
2RMX	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A Descriptor: NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6 Authors: Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-11-30 Release date: 2008-12-02 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1 To be Published
3IMJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester, Growth factor receptor-bound protein 2 Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IN8	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide Authors: Benfield, A.P, Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
2ROR	Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 Descriptor: 15-meric peptide from Lymphocyte cytosolic protein 2, Proto-oncogene vav Authors: Tanaka, M, Kasai, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2008-04-08 Release date: 2009-04-21 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 To be Published
2RVF	Solution NMR structure of Monosiga brevicollis CRK/CRKL homolog (crka1) SH2 domain Descriptor: Predicted protein Authors: Kasai, T, Pawlak, J, Imamoto, A, Kigawa, T. Deposit date: 2015-09-24 Release date: 2016-09-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: A pre-metazoan origin of the CRK gene family and co-opted signaling network Sci Rep, 6, 2016
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide Authors: Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
2VIF	Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide Descriptor: 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6 Authors: Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S. Deposit date: 2007-11-30 Release date: 2007-12-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286, 2011
3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex Descriptor: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Duguid, E. Deposit date: 2009-09-30 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
2QMS	Crystal structure of a signaling molecule Descriptor: Growth factor receptor-bound protein 7, SULFATE ION Authors: Porter, C.J, Wilce, M.C, Wilce, J.A. Deposit date: 2007-07-16 Release date: 2008-07-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. Bmc Struct.Biol., 7, 2007
1WQU	Solution structure of the human FES SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS Authors: Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-10-02 Release date: 2005-06-14 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
1X0N	NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor Descriptor: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 Authors: Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. Deposit date: 2005-03-24 Release date: 2005-04-19 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 Descriptor: Tyrosine-protein phosphatase, non-receptor type 6 Authors: Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-17 Release date: 2005-11-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
6KC4	Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD) Descriptor: Tyrosine-protein kinase Fer, phosphopeptide (EDpYENVD) Authors: Matsuura, Y. Deposit date: 2019-06-27 Release date: 2019-09-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.37 Å) Cite: High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase. Protein Sci., 28, 2019
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION Authors: Rahuel, J. Deposit date: 1998-03-26 Release date: 1999-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
5GJH	Gads SH2 domain/CD28-derived peptide complex Descriptor: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Hajicek, N, Sondek, J. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2017-05-10 Method: X-RAY DIFFRACTION (0.9 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide Authors: Sondek, J, Hajicek, N. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2014-01-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013

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