7KUG
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![BU of 7kug by Molmil](/molmil-images/mine/7kug) | Fe-S cluster-bound transcription activator WhiB7 in complex with the SigmaAr4-RNAP Beta flap tip chimera | Descriptor: | IRON/SULFUR CLUSTER, Probable transcriptional regulator WhiB7, RNA polymerase sigma factor, ... | Authors: | Wan, T, Horova, M, Beltran, D.G, Li, S.R, Zhang, L.M. | Deposit date: | 2020-11-24 | Release date: | 2021-06-30 | Last modified: | 2021-10-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis. Mol.Cell, 81, 2021
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7OFW
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![BU of 7ofw by Molmil](/molmil-images/mine/7ofw) | Nontypeable Haemophillus influenzae SapA in complex with heme | Descriptor: | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ... | Authors: | Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A. | Deposit date: | 2021-05-05 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif. Plos One, 16, 2021
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6K3Z
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![BU of 6k3z by Molmil](/molmil-images/mine/6k3z) | Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | Descriptor: | CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | Deposit date: | 2019-05-22 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
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5TJG
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4TU7
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![BU of 4tu7 by Molmil](/molmil-images/mine/4tu7) | Structure of U2AF65 D231V variant with BrU5 DNA | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2014-06-24 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
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1D9D
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![BU of 1d9d by Molmil](/molmil-images/mine/1d9d) | CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3' | Descriptor: | 5'-D(*TP*CP*GP)-R(AP*(U31)P*(C31))-3', DNA POLYMERASE I, MAGNESIUM ION, ... | Authors: | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | Deposit date: | 1999-10-27 | Release date: | 1999-12-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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4J5Y
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![BU of 4j5y by Molmil](/molmil-images/mine/4j5y) | Crystal structure of Hfq from Pseudomonas aeruginosa in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Protein hfq, ... | Authors: | Murina, V, Lekontseva, N, Nikulin, A. | Deposit date: | 2013-02-11 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.0953 Å) | Cite: | Hfq binds ribonucleotides in three different RNA-binding sites. Acta Crystallogr.,Sect.D, 69, 2013
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3V74
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![BU of 3v74 by Molmil](/molmil-images/mine/3v74) | crystal structure of FBF-2 in complex with gld-1 FBEa13 RNA | Descriptor: | Fem-3 mRNA-binding factor 2, RNA (5'-R(*UP*CP*AP*UP*GP*UP*GP*CP*CP*AP*UP*AP*C)-3') | Authors: | Wang, Y, Qiu, C, Kershner, A, Holley, C.P, Wilinski, D, Keles, S, Kimble, J, Wickens, M, Hall, T.M.T. | Deposit date: | 2011-12-20 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Divergence of PUF protein specificity through variations in an RNA-binding pocket J.Biol.Chem., 2012
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5ZVS
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5K0M
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![BU of 5k0m by Molmil](/molmil-images/mine/5k0m) | Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED | Descriptor: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED | Authors: | Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. | Deposit date: | 2016-05-17 | Release date: | 2017-01-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13, 2017
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8EXA
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![BU of 8exa by Molmil](/molmil-images/mine/8exa) | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 1 (RuvC domain resolved) | Descriptor: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | Authors: | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | Deposit date: | 2022-10-25 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616, 2023
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8EX9
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![BU of 8ex9 by Molmil](/molmil-images/mine/8ex9) | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 2 (RuvC domain unresolved) | Descriptor: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | Authors: | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | Deposit date: | 2022-10-25 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616, 2023
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8ORQ
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![BU of 8orq by Molmil](/molmil-images/mine/8orq) | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase open clamp conformation | Descriptor: | DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... | Authors: | Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | Deposit date: | 2023-04-17 | Release date: | 2024-04-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
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8OKI
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![BU of 8oki by Molmil](/molmil-images/mine/8oki) | Cryo-EM structure of Pyrococcus furiosus transcription elongation complex bound to Spt4/5 | Descriptor: | DNA Non-Template Strand, DNA Template Strand, DNA-directed RNA polymerase subunit Rpo10, ... | Authors: | Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | Deposit date: | 2023-03-28 | Release date: | 2024-04-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
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5OSY
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![BU of 5osy by Molmil](/molmil-images/mine/5osy) | Human Decapping Scavenger enzyme (hDcpS) in complex with m7G(5'S)ppSp(5'S)G mRNA 5' cap analog | Descriptor: | GLYCEROL, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid, m7GpppX diphosphatase | Authors: | Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M. | Deposit date: | 2017-08-18 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc., 140, 2018
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7NHI
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![BU of 7nhi by Molmil](/molmil-images/mine/7nhi) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 | Descriptor: | (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-10 | Release date: | 2021-09-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NHG
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7NIA
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![BU of 7nia by Molmil](/molmil-images/mine/7nia) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ059a | Descriptor: | 4-[[(3R)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NI9
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![BU of 7ni9 by Molmil](/molmil-images/mine/7ni9) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ058 | Descriptor: | ACETATE ION, N-(((R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-(((S)-1-isopropyl-2-azaspiro[3.3]heptan-2-yl)methyl)benzamide, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NHV
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![BU of 7nhv by Molmil](/molmil-images/mine/7nhv) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | Descriptor: | (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NHH
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7NI7
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![BU of 7ni7 by Molmil](/molmil-images/mine/7ni7) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | Descriptor: | (R)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxy-N-((3-hydroxy-1-(6-((3-(methylcarbamoyl)benzyl)amino)pyrimidin-4-yl)piperidin-3-yl)methyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NID
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![BU of 7nid by Molmil](/molmil-images/mine/7nid) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | Descriptor: | (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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7NHJ
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7NI8
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![BU of 7ni8 by Molmil](/molmil-images/mine/7ni8) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ040a | Descriptor: | (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | Deposit date: | 2021-02-11 | Release date: | 2021-10-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
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