8EXA
ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 1 (RuvC domain resolved)
Summary for 8EXA
| Entry DOI | 10.2210/pdb8exa/pdb |
| Related | 8BF8 8EX9 |
| EMDB information | 16016 28655 28656 |
| Descriptor | RNA-guided DNA endonuclease TnpB, RNA (150-MER), DNA (43-MER), ... (4 entities in total) |
| Functional Keywords | transposon, tnpb, ruvc domain, cas12, is200/is605, rerna, rna binding protein |
| Biological source | Deinococcus radiodurans R1 More |
| Total number of polymer chains | 4 |
| Total formula weight | 121424.93 |
| Authors | Sasnauskas, G.,Tamulaitiene, G.,Carabias, A.,Karvelis, T.,Druteika, G.,Silanskas, A.,Montoya, G.,Venclovas, C.,Kazlauskas, D.,Siksnys, V. (deposition date: 2022-10-25, release date: 2023-04-05, Last modification date: 2024-06-19) |
| Primary citation | Sasnauskas, G.,Tamulaitiene, G.,Druteika, G.,Carabias, A.,Silanskas, A.,Kazlauskas, D.,Venclovas, C.,Montoya, G.,Karvelis, T.,Siksnys, V. TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616:384-389, 2023 Cited by PubMed: 37020015DOI: 10.1038/s41586-023-05826-x PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.14 Å) |
Structure validation
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