4TU7

Structure of U2AF65 D231V variant with BrU5 DNA

Summary for 4TU7

• Entry DOI: 10.2210/pdb4tu7/pdb
• Related: 4TU8 4TU9
• Descriptor: Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), 1,4-DIETHYLENE DIOXIDE, ... (7 entities in total)
• Functional Keywords: pre-mrna splicing factor, rna recognition motif, rna binding protein-dna complex, rna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P26368
• Total number of polymer chains: 4
• Total formula weight: 44409.04

Authors

Agrawal, A.A.,Jenkins, J.L.,Kielkopf, C.L. (deposition date: 2014-06-24, release date: 2014-11-26, Last modification date: 2023-12-27)

• Primary citation: Agrawal, A.A.,McLaughlin, K.J.,Jenkins, J.L.,Kielkopf, C.L.; Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.; Proc.Natl.Acad.Sci.USA, 111:17420-17425, 2014; PubMed: 25422459; DOI: 10.1073/pnas.1412743111

Experimental method

X-RAY DIFFRACTION (2.087 Å)