1F3X
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![BU of 1f3x by Molmil](/molmil-images/mine/1f3x) | S402P MUTANT OF RABBIT MUSCLE PYRUVATE KINASE | Descriptor: | MANGANESE (II) ION, POTASSIUM ION, PYRUVATE KINASE, ... | Authors: | Wooll, J.O, Friesen, R.H.E, White, M.A, Watowich, S.J, Fox, R.O, Lee, J.C, Czerwinski, E.W. | Deposit date: | 2000-06-06 | Release date: | 2001-10-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase. J.Mol.Biol., 312, 2001
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5F6V
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![BU of 5f6v by Molmil](/molmil-images/mine/5f6v) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol from fragment cocktail screen) | Descriptor: | 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.492 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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3NQU
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1IVT
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![BU of 1ivt by Molmil](/molmil-images/mine/1ivt) | NMR structures of the C-terminal globular domain of human lamin A/C | Descriptor: | Lamin A/C | Authors: | Krimm, I, Ostlund, C, Gilquin, B, Couprie, J, Hossenlopp, P, Mornon, J.P, Bonn, G, Courvalin, J.C, Worman, H.J, Zinn-Justin, S. | Deposit date: | 2002-03-29 | Release date: | 2002-08-21 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. Structure, 10, 2002
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5F6X
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![BU of 5f6x by Molmil](/molmil-images/mine/5f6x) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6E
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![BU of 5f6e by Molmil](/molmil-images/mine/5f6e) | Crystal Structure of human Ubc9 (K48A/K49A/E54A) | Descriptor: | 1,2-ETHANEDIOL, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-05 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6U
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![BU of 5f6u by Molmil](/molmil-images/mine/5f6u) | Crystal Structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 8 (JSS190B146) | Descriptor: | SUMO-conjugating enzyme UBC9, ethyl 3-[4-(2-hydroxyphenyl)-3-oxidanyl-phenyl]propanoate | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6Y
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![BU of 5f6y by Molmil](/molmil-images/mine/5f6y) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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1JEY
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![BU of 1jey by Molmil](/molmil-images/mine/1jey) | Crystal Structure of the Ku heterodimer bound to DNA | Descriptor: | DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), Ku70, ... | Authors: | Walker, J.R, Corpina, R.A, Goldberg, J. | Deposit date: | 2001-06-19 | Release date: | 2001-08-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 2001
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3O33
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1FJE
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![BU of 1fje by Molmil](/molmil-images/mine/1fje) | SOLUTION STRUCTURE OF NUCLEOLIN RBD12 IN COMPLEX WITH SNRE RNA | Descriptor: | NUCLEOLIN RBD12, SNRE RNA | Authors: | Allain, F.H.T, Bouvet, P, Dieckmann, T, Feigon, J. | Deposit date: | 2000-08-08 | Release date: | 2001-01-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin. EMBO J., 19, 2000
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1FJ7
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1K5D
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![BU of 1k5d by Molmil](/molmil-images/mine/1k5d) | Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex | Descriptor: | GTP-binding nuclear protein RAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R. | Deposit date: | 2001-10-10 | Release date: | 2002-02-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | RanGAP mediates GTP hydrolysis without an arginine finger. Nature, 415, 2002
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5F6D
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![BU of 5f6d by Molmil](/molmil-images/mine/5f6d) | Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 | Descriptor: | 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-05 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5GSU
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![BU of 5gsu by Molmil](/molmil-images/mine/5gsu) | Crystal structure of nucleosome core particle consisting of human testis-specific histone variants, Th2A and Th2B | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-A, ... | Authors: | Kumarevel, T, Sivaraman, P. | Deposit date: | 2016-08-17 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b Biophys. Chem., 221, 2017
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5FQ2
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1GK7
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![BU of 1gk7 by Molmil](/molmil-images/mine/1gk7) | HUMAN VIMENTIN COIL 1A FRAGMENT (1A) | Descriptor: | SULFATE ION, VIMENTIN | Authors: | Strelkov, S.V, Herrmann, H, Geisler, N, Zimbelmann, R, Aebi, U, Burkhard, P. | Deposit date: | 2001-08-08 | Release date: | 2002-03-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Conserved Segments 1A and 2B of the Intermediate Filament Dimer: Their Atomic Structures and Role in Filament Assembly. Embo J., 21, 2002
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3N25
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![BU of 3n25 by Molmil](/molmil-images/mine/3n25) | The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+ | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Fenton, A.W, Johnson, T.A, Holyoak, T. | Deposit date: | 2010-05-17 | Release date: | 2010-07-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., 19, 2010
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5GT3
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![BU of 5gt3 by Molmil](/molmil-images/mine/5gt3) | Crystal structure of nucleosome particle in the presence of human testis-specific histone variant, hTh2b | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-D, ... | Authors: | Kumarevel, T, Sivaraman, P. | Deposit date: | 2016-08-18 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b Biophys. Chem., 221, 2017
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3ODC
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![BU of 3odc by Molmil](/molmil-images/mine/3odc) | Human PARP-1 zinc finger 2 (Zn2) bound to DNA | Descriptor: | 5'-D(*CP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ... | Authors: | Pascal, J.M, Langelier, M.-F. | Deposit date: | 2010-08-11 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY. J.Biol.Chem., 286, 2011
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1H8A
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![BU of 1h8a by Molmil](/molmil-images/mine/1h8a) | CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3 | Descriptor: | CAAT/ENHANCER BINDING PROTEIN BETA, DNA(5'-(*CP*CP*AP*GP*TP*CP*CP*GP*TP*TP*AP* AP*GP*GP*AP*TP*TP*GP*CP*GP*CP*CP*AP*CP*AP*T)-3'), DNA(5'-(*GP*AP*TP*GP*TP*GP*GP*CP*GP*CP*AP* AP*TP*CP*CP*TP*TP*AP*AP*CP*GP*GP*AP*CP*TP*G)-3'), ... | Authors: | Tahirov, T.H, Ogata, K. | Deposit date: | 2001-01-31 | Release date: | 2002-01-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Mechanism of C-Myb-C/Ebpbeta Cooperation from Separated Sites on a Promoter Cell(Cambridge,Mass.), 108, 2002
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1GU4
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1GU5
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1GTW
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1K4T
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![BU of 1k4t by Molmil](/molmil-images/mine/1k4t) | HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | Authors: | Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J. | Deposit date: | 2001-10-08 | Release date: | 2002-12-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The mechanism of topoisomerase I poisoning by a camptothecin analog Proc.Natl.Acad.Sci.USA, 99, 2002
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