5F6E

Crystal Structure of human Ubc9 (K48A/K49A/E54A)

Summary for 5F6E

Entry DOI	10.2210/pdb5f6e/pdb
Related	5F6D 5F6U 5F6V 5F6W 5F6X 5F6Y
Descriptor	SUMO-conjugating enzyme UBC9, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	ubc9, sumoylation, drug discovery, ligase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P63279
Total number of polymer chains	1
Total formula weight	17787.44
Authors	Lountos, G.T.,Hewitt, W.M.,Zlotkowski, Z.,Dahlhauser, S.,Saunders, L.B.,Needle, D.,Tropea, J.E.,Zhan, C.,Wei, G.,Ma, B.,Nussinov, R.,Schneekloth, J.S.Jr.,Waugh, D.S. (deposition date: 2015-12-05, release date: 2016-04-27, Last modification date: 2023-09-27)
Primary citation	Hewitt, W.M.,Lountos, G.T.,Zlotkowski, K.,Dahlhauser, S.D.,Saunders, L.B.,Needle, D.,Tropea, J.E.,Zhan, C.,Wei, G.,Ma, B.,Nussinov, R.,Waugh, D.S.,Schneekloth, J.S. Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55:5703-5707, 2016 Cited by PubMed: 27038327 DOI: 10.1002/anie.201511351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.12 Å)

Structure validation