3N25
The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+
Summary for 3N25
| Entry DOI | 10.2210/pdb3n25/pdb |
| Descriptor | Pyruvate kinase isozymes M1/M2, PROLINE, MANGANESE (II) ION, ... (9 entities in total) |
| Functional Keywords | pyruvate kinase, glycolysis, allosteric regulation, transferase |
| Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
| Cellular location | Cytoplasm : P11974 |
| Total number of polymer chains | 8 |
| Total formula weight | 470150.38 |
| Authors | Fenton, A.W.,Johnson, T.A.,Holyoak, T. (deposition date: 2010-05-17, release date: 2010-07-28, Last modification date: 2023-11-15) |
| Primary citation | Fenton, A.W.,Johnson, T.A.,Holyoak, T. The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., 19:1796-1800, 2010 Cited by PubMed: 20629175DOI: 10.1002/pro.450 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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