3N25

The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Pyruvate kinase isozymes M1/M2	polymer	531	58102.0	8	UniProt (P11974) Pfam (PF00224) Pfam (PF02887) In PDB	Oryctolagus cuniculus (European rabbit Japanese white rabbit domestic rabbit rabbits)	Pyruvate kinase muscle isozyme
2	H, C, A, F, D...	PROLINE	non-polymer		115.1	8	Chemie (PRO)
3	H, C, A, F, D...	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
4	E, H, C, A, F...	PYRUVIC ACID	non-polymer		88.1	8	Chemie (PYR)
5	E, H, C, A, F...	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
6	E, H, C, A, F...	SODIUM ION	non-polymer		23.0	12	Chemie (NA)
7	B, H, E, C, D...	GLYCEROL	non-polymer		92.1	19	Chemie (GOL)
8	B, E, H, C, A...	1,2-ETHANEDIOL	non-polymer		62.1	15	Chemie (EDO)
9		water	water		18.0	1427	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 0 - 530 (UniProt: P11974)

PDB	External Database	Details
Lys 29	Met 30	SEE REMARK 999
Ala 400	Ser 401	SEE REMARK 999
Gln 403	His 404	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	464815.9
Non-Polymers*	Number of molecules	78
	Total formula weight	5334.5
All*	Total formula weight	470150.4

*Water molecules are not included.