1BRT
| BROMOPEROXIDASE A2 MUTANT M99T | Descriptor: | BROMOPEROXIDASE A2, CHLORIDE ION | Authors: | Hofmann, B, Toelzer, S, Pelletier, I, Altenbuchner, J, Van Pee, K.H, Hecht, H.J. | Deposit date: | 1998-03-30 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural investigation of the cofactor-free chloroperoxidases. J.Mol.Biol., 279, 1998
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1D07
| Hydrolytic haloalkane dehalogenase linb from sphingomonas paucimobilis UT26 with 1,3-propanediol, a product of debromidation of dibrompropane, at 2.0A resolution | Descriptor: | 1,3-PROPANDIOL, BROMIDE ION, HALOALKANE DEHALOGENASE | Authors: | Marek, J, Vevodova, J, Damborsky, J, Smatanova, I, Svensson, L.A, Newman, J, Nagata, Y, Takagi, M. | Deposit date: | 1999-09-09 | Release date: | 2000-09-11 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26. Biochemistry, 39, 2000
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1EX9
| CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LIPASE COMPLEXED WITH RC-(RP,SP)-1,2-DIOCTYLCARBAMOYL-GLYCERO-3-O-OCTYLPHOSPHONATE | Descriptor: | CALCIUM ION, LACTONIZING LIPASE, OCTYL-PHOSPHINIC ACID 1,2-BIS-OCTYLCARBAMOYLOXY-ETHYL ESTER | Authors: | Nardini, M, Lang, D.A, Liebeton, K, Jaeger, K.-E, Dijkstra, B.W. | Deposit date: | 2000-05-02 | Release date: | 2000-10-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Crystal structure of pseudomonas aeruginosa lipase in the open conformation. The prototype for family I.1 of bacterial lipases. J.Biol.Chem., 275, 2000
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1EB8
| Structure Determinants of Substrate Specificity of Hydroxynitrile Lyase from Manihot esculenta | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (S)-ACETONE-CYANOHYDRIN LYASE | Authors: | Lauble, H, Miehlich, B, Foerster, S, Kobler, C, Wajant, H, Effenberger, F. | Deposit date: | 2001-07-24 | Release date: | 2002-01-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure Determinants of Substrate Specificity of Hydroxynitrile Lyase from Manihot Esculenta. Protein Sci., 11, 2002
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4YK7
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4Y7D
| Alpha/beta hydrolase fold protein from Nakamurella multipartita | Descriptor: | Alpha/beta hydrolase fold protein, CHLORIDE ION, SODIUM ION | Authors: | Cuff, M.E, OSIPIUK, J, Holowicki, J, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-02-14 | Release date: | 2015-02-25 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Alpha/beta hydrolase fold protein from Nakamurella multipartita. to be published
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5A62
| Hydrolytic potential of the ammonia-oxidizing Thaumarchaeon Nitrososphaera gargenis - crystal structure and activity profiles of carboxylesterases linked to their metabolic function | Descriptor: | ACETATE ION, PUTATIVE ALPHA/BETA HYDROLASE FOLD PROTEIN | Authors: | Chow, J, Kaljunen, H, Nittinger, E, Spieck, E, Rarey, M, Mueller-Dieckmann, J, Streit, W.R. | Deposit date: | 2015-06-24 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Hydrolytic Potential of the Ammonia-Oxidizing Thaumarchaeon Nitrososphaera Gargenis - Crystal Structure and Activity Profiles of Carboxylesterases Linked to Their Metabolic Function To be Published
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4YAS
| HYDROXYNITRILE LYASE COMPLEXED WITH CHLORALHYDRATE | Descriptor: | PROTEIN (HYDROXYNITRILE LYASE), SULFATE ION, TRI-CHLORO-ACETALDEHYDE | Authors: | Zuegg, J, Wagner, U.G, Gugganig, M, Kratky, C. | Deposit date: | 1999-03-15 | Release date: | 1999-10-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Protein Sci., 8, 1999
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4Y9S
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3KOO
| Crystal Structure of soluble epoxide Hydrolase | Descriptor: | Epoxide hydrolase 2, N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide | Authors: | Farrow, N.A. | Deposit date: | 2009-11-13 | Release date: | 2010-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.791 Å) | Cite: | Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. Bioorg.Med.Chem.Lett., 20, 2010
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8B6Q
| X-ray structure of the haloalkane dehalogenase HaloTag7 with an insertion of Calmodulin-M13 fusion at position 154-156 that mimic the structure of CaProLa, an calcium gated protein labeling technology | Descriptor: | CALCIUM ION, CHLORIDE ION, Haloalkane dehalogenase,Calmodulin-1,Haloalkane dehalogenase,Calmodulin-1,M13 peptide | Authors: | Tarnawski, M, Johnsson, K, Hiblot, J. | Deposit date: | 2022-09-27 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | X-ray structure of the haloalkane dehalogenase HaloTag7 with an insertion of Calmodulin-M13 fusion at position 154-156 that mimic the structure of CaProLa, an calcium gated protein labeling technology To Be Published
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3OTQ
| Soluble Epoxide Hydrolase in complex with pyrazole antagonist | Descriptor: | Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide | Authors: | Farrow, N.A. | Deposit date: | 2010-09-13 | Release date: | 2010-10-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain. Bioorg.Med.Chem.Lett., 20, 2010
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8G5U
| Crystal structure of TnmK2 complexed with TNM B | Descriptor: | TnmK2, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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8G5T
| Crystal structure of apo TnmK2 | Descriptor: | TnmK2 | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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4Y2Q
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4Y2R
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4Y2X
| Structure of soluble epoxide hydrolase in complex with 2-({[2-(adamantan-1-yl)ethyl]amino}methyl)phenol | Descriptor: | 2-[({2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]ethyl}amino)methyl]phenol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION | Authors: | Amano, Y, Yamaguchi, T. | Deposit date: | 2015-02-10 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
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4Y2Y
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4Y2U
| Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Descriptor: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Authors: | Amano, Y, Yamaguchi, T. | Deposit date: | 2015-02-10 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
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4Y2J
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4Y2P
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5FP0
| ligand complex structure of soluble epoxide hydrolase | Descriptor: | BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide | Authors: | Xue, Y, Olsson, T, Johansson, C.A, Oster, L, Beisel, H.G, Rohman, M, Karis, D, Backstrom, S. | Deposit date: | 2015-11-26 | Release date: | 2016-03-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration. Chemmedchem, 11, 2016
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3I1Y
| Crystal Structure of soluble epoxide Hydrolase | Descriptor: | Epoxide hydrolase 2, N-(3,3-diphenylpropyl)pyridine-3-carboxamide | Authors: | Farrow, N.A. | Deposit date: | 2009-06-28 | Release date: | 2009-10-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.469 Å) | Cite: | Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J.Med.Chem., 52, 2009
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3I28
| Crystal Structure of soluble epoxide Hydrolase | Descriptor: | 4-cyano-N-{(3S)-3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}benzamide, Epoxide hydrolase 2 | Authors: | Farrow, N.A. | Deposit date: | 2009-06-29 | Release date: | 2009-10-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J.Med.Chem., 52, 2009
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8QVI
| Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound. | Descriptor: | Bifunctional epoxide hydrolase 2, DI(HYDROXYETHYL)ETHER | Authors: | Dunge, A, Uwangue, O, Phan, C, Bjelcic, M, Gunnarsson, J, Wehlander, G, Kack, H, Branden, G. | Deposit date: | 2023-10-18 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Exploring serial crystallography for drug discovery To Be Published
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