4Y2X

Structure of soluble epoxide hydrolase in complex with 2-({[2-(adamantan-1-yl)ethyl]amino}methyl)phenol

Summary for 4Y2X

Entry DOI	10.2210/pdb4y2x/pdb
Related	4y2j 4y2p 4y2q 4y2r 4y2s 4y2t 4y2u 4y2v 4y2y
Descriptor	Bifunctional epoxide hydrolase 2, MAGNESIUM ION, 2-[({2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]ethyl}amino)methyl]phenol, ... (4 entities in total)
Functional Keywords	hydrolase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P34913
Total number of polymer chains	1
Total formula weight	63824.24
Authors	Amano, Y.,Yamaguchi, T. (deposition date: 2015-02-10, release date: 2015-05-06, Last modification date: 2023-11-08)
Primary citation	Amano, Y.,Tanabe, E.,Yamaguchi, T. Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23:2310-2317, 2015 Cited by PubMed: 25862210 DOI: 10.1016/j.bmc.2015.03.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation