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3C33	Crystal structure of GluR5 ligand-binding core in complex with potassium at 1.78 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3C36	Crystal structure of GluR5 ligand-binding core in complex with ammonium ions at 1.68 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, AMMONIUM ION, CHLORIDE ION, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3C34	Crystal structure of GluR5 ligand-binding core in complex with rubidium at 1.82 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3FAS	X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-glutamate at 1.40A resolution Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 4, ... Authors: Kasper, C, Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2008-11-18 Release date: 2008-12-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 Febs Lett., 582, 2008
3H03	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 Descriptor: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2009-04-08 Release date: 2009-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H6W	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution Descriptor: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3G3H	Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3K	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FV1	Crystal Structure of the human glutamate receptor, GluR5, ligand-binding core in complex with dysiherbaine in space group P1 Descriptor: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3G3J	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant with glutamate and NaCl at 1.32 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.321 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FVG	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with MSVIII-19 in space group P1 Descriptor: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3G3I	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.371 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3GBA	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A resolution Descriptor: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ... Authors: Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-02-19 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3FVK	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-deoxy-neodysiherbaine A in space group P1 Descriptor: (2R,3aR,6S,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-6-hydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3G3G	Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.303 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FUZ	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with L-glutamate in space group P1 Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3FVO	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1 Descriptor: (2R,3aR,6R,7S,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-6,7-dihydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-16 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structures of Human GluR5 Ligand-Binding Core in Complexes with Novel Marine-Derived Toxins, Dysiherbaine and Neodysiherbaine A, and Their Analogues To be Published
3FVN	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 9-deoxy-neodysiherbaine A in space group P1 Descriptor: (2R,3aR,7R,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-7-hydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-16 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3G3F	Crystal structure of the GluR6 ligand binding domain dimer with glutamate and NaCl at 1.38 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.377 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FV2	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with neodysiherbaine A in space group P1 Descriptor: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3GBB	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution Descriptor: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, Glutamate receptor, ionotropic kainate 1 Authors: Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-02-19 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3IL1	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 Descriptor: (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2009-08-06 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3ILT	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide Descriptor: 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2009-08-07 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.107 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3H6T	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution Descriptor: ACETATE ION, CACODYLATE ION, CYCLOTHIAZIDE, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6V	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution Descriptor: (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009

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