6KBN
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![BU of 6kbn by Molmil](/molmil-images/mine/6kbn) | Crystal structure of Vac8 (del 19-33) bound to Atg13 | Descriptor: | Autophagy-related protein 13, Vacuolar protein 8 | Authors: | Park, J, Lee, C. | Deposit date: | 2019-06-25 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways. Autophagy, 16, 2020
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6KBM
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![BU of 6kbm by Molmil](/molmil-images/mine/6kbm) | Crystal structure of Vac8 bound to Atg13 | Descriptor: | Autophagy-related protein 13, Vacuolar protein 8 | Authors: | Park, J, Lee, C. | Deposit date: | 2019-06-25 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.902 Å) | Cite: | Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways. Autophagy, 16, 2020
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1G3J
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![BU of 1g3j by Molmil](/molmil-images/mine/1g3j) | CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX | Descriptor: | BETA-CATENIN ARMADILLO REPEAT REGION, TCF3-CBD (CATENIN BINDING DOMAIN) | Authors: | Graham, T.A, Weaver, C, Mao, F, Kimelman, D, Xu, W. | Deposit date: | 2000-10-24 | Release date: | 2000-12-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a beta-catenin/Tcf complex. Cell(Cambridge,Mass.), 103, 2000
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4DJS
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![BU of 4djs by Molmil](/molmil-images/mine/4djs) | Structure of beta-catenin in complex with a stapled peptide inhibitor | Descriptor: | Catenin beta-1, stapled peptide RRWPQ(MK8)ILD(MK8)HVRRVWR | Authors: | Bowman, B.R, Grossmann, T.N, Yeh, J.T.-H, Verdine, G.L. | Deposit date: | 2012-02-02 | Release date: | 2012-10-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.029 Å) | Cite: | Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin. Proc.Natl.Acad.Sci.USA, 109, 2012
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8Y0G
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![BU of 8y0g by Molmil](/molmil-images/mine/8y0g) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-01-22 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal protein of human Beta-catenin To Be Published
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8Y14
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![BU of 8y14 by Molmil](/molmil-images/mine/8y14) | Beta-catenin Crystal Structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-01-23 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Beta-catenin Crystal Structure To Be Published
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8Z10
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![BU of 8z10 by Molmil](/molmil-images/mine/8z10) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1, PROLINE | Authors: | Tim, F. | Deposit date: | 2024-04-10 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of Beta-catenin To Be Published
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8Z5J
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![BU of 8z5j by Molmil](/molmil-images/mine/8z5j) | Beta-catenin Crystal Structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-04-18 | Release date: | 2024-05-22 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 2024
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8Z61
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![BU of 8z61 by Molmil](/molmil-images/mine/8z61) | Human beta-catenin crystal structure | Descriptor: | Catenin beta-1 | Authors: | Tim, F. | Deposit date: | 2024-04-18 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 2024
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8Z0U
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![BU of 8z0u by Molmil](/molmil-images/mine/8z0u) | |
4R0Z
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![BU of 4r0z by Molmil](/molmil-images/mine/4r0z) | A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo | Descriptor: | FORMIC ACID, Protein humpback-2 | Authors: | Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. | Deposit date: | 2014-08-03 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.005 Å) | Cite: | A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
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3SLA
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![BU of 3sla by Molmil](/molmil-images/mine/3sla) | X-ray structure of first four repeats of human beta-catenin | Descriptor: | Catenin beta-1, GLYCEROL, SODIUM ION | Authors: | Gupta, D, Bienz, M. | Deposit date: | 2011-06-24 | Release date: | 2012-02-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 2012
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3TT9
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![BU of 3tt9 by Molmil](/molmil-images/mine/3tt9) | Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant | Descriptor: | GLYCEROL, Plakophilin-2 | Authors: | Schuetz, A, Roske, Y, Gerull, B, Heinemann, U. | Deposit date: | 2011-09-14 | Release date: | 2012-08-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet, 5, 2012
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3BTR
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![BU of 3btr by Molmil](/molmil-images/mine/3btr) | AR-NLS:Importin-alpha complex | Descriptor: | Androgen receptor, Importin subunit alpha-2 | Authors: | Cutress, M.L, Whitaker, H.C, Mills, I.G, Stewart, M, Neal, D.E. | Deposit date: | 2007-12-30 | Release date: | 2008-12-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the nuclear import of the human androgen receptor J.Cell.Sci., 121, 2008
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5IZA
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![BU of 5iza by Molmil](/molmil-images/mine/5iza) | Protein-protein interaction | Descriptor: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | Deposit date: | 2016-03-25 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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6N89
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![BU of 6n89 by Molmil](/molmil-images/mine/6n89) | |
4WV6
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![BU of 4wv6 by Molmil](/molmil-images/mine/4wv6) | Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8 | Descriptor: | 1,2-ETHANEDIOL, Importin subunit alpha-1, Transcription initiation factor TFIID subunit 8 | Authors: | Trowitzsch, S. | Deposit date: | 2014-11-04 | Release date: | 2015-01-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. Nat Commun, 6, 2015
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8ECH
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![BU of 8ech by Molmil](/molmil-images/mine/8ech) | |
6IWA
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![BU of 6iwa by Molmil](/molmil-images/mine/6iwa) | Crystal structure of Importin-alpha and phosphoserine GM130 | Descriptor: | Importin subunit alpha-1, PHOSPHOSERINE GM130 | Authors: | Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. | Deposit date: | 2018-12-05 | Release date: | 2019-10-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
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2QNA
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![BU of 2qna by Molmil](/molmil-images/mine/2qna) | Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65) | Descriptor: | Importin subunit beta-1, SULFATE ION, Snurportin-1 | Authors: | Wohlwend, D, Strasser, A, Dickmanns, A, Ficner, R. | Deposit date: | 2007-07-18 | Release date: | 2008-04-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus. J.Mol.Biol., 374, 2007
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1QGR
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![BU of 1qgr by Molmil](/molmil-images/mine/1qgr) | STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH) | Descriptor: | PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) | Authors: | Cingolani, G, Petosa, C, Weis, K, Muller, C.W. | Deposit date: | 1999-05-04 | Release date: | 1999-05-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
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6P6E
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![BU of 6p6e by Molmil](/molmil-images/mine/6p6e) | Structure of Mouse Importin alpha - PAC3 NLS peptide complex | Descriptor: | Importin subunit alpha-1, PAC3 NLS | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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1QGK
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![BU of 1qgk by Molmil](/molmil-images/mine/1qgk) | STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA | Descriptor: | PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) | Authors: | Cingolani, G, Petosa, C, Weis, K, Muller, C.W. | Deposit date: | 1999-04-29 | Release date: | 1999-05-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
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5B56
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![BU of 5b56 by Molmil](/molmil-images/mine/5b56) | Crystal structure of HIV-1 VPR C-Terminal domain and DIBB-M-Importin-Alpha2 complex | Descriptor: | Importin subunit alpha-1, Protein Vpr | Authors: | Miyatake, H, Sanjoh, A, Matusda, G, Murakami, T, Murakami, H, Hagiwara, K, Yokoyama, M, Sato, H, Miyamoto, Y, Dohmae, N, Aida, Y. | Deposit date: | 2016-04-25 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha J.Mol.Biol., 428, 2016
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6P6A
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![BU of 6p6a by Molmil](/molmil-images/mine/6p6a) | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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