Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)

Summary for 2QNA

DescriptorImportin subunit beta-1, Snurportin-1, SULFATE ION, ... (4 entities in total)
Functional Keywordsnuclear transport, import of spliceosomal subunits, protein-protein interaction, heat-repeat protein, host-virus interaction, nucleus, protein transport, rna-binding, transport protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q14974
Nucleus  O95149
Total number of polymer chains2
Total molecular weight92437.16
Wohlwend, D.,Strasser, A.,Dickmanns, A.,Ficner, R. (deposition date: 2007-07-18, release date: 2008-04-08, Last modification date: 2017-10-25)
Primary citation
Wohlwend, D.,Strasser, A.,Dickmanns, A.,Ficner, R.
Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus.
J.Mol.Biol., 374:1129-1138, 2007
PubMed: 18028944 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.09.065
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27830 4.8% 6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-12-02