2GVZ
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2W01
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2WZ1
| STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLE GUANYLATE CYCLASE 1 BETA 3. | Descriptor: | 1,2-ETHANEDIOL, GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 | Authors: | Allerston, C.K, Cooper, C.D.O, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2009-11-23 | Release date: | 2009-12-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One, 8, 2013
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3C14
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3C15
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3C16
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3ET6
| The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase | Descriptor: | PHOSPHATE ION, Soluble guanylyl cyclase beta | Authors: | Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. | Deposit date: | 2008-10-07 | Release date: | 2008-10-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol., 8, 2008
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3G82
| Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP and Mn | Descriptor: | 3'-O-{[2-(methylamino)phenyl]carbonyl}inosine 5'-(tetrahydrogen triphosphate), 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 2, ... | Authors: | Huebner, M, Mou, T.-C, Sprang, S.R, Seifert, R. | Deposit date: | 2009-02-11 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | 2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin To be Published
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3MAA
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3MR7
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3R5G
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3UVJ
| Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Guanylate cyclase soluble subunit alpha-3, ... | Authors: | Allerston, C.K, Berridge, G, Chalk, R, Cooper, C.D.O, Savitsky, P, Vollmar, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Gileadi, O, Structural Genomics Consortium (SGC) | Deposit date: | 2011-11-30 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structures of the catalytic domain of human soluble guanylate cyclase. Plos One, 8, 2013
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4CLF
| Crystal structure of human soluble Adenylyl Cyclase (Apo form) | Descriptor: | ACETATE ION, ADENYLATE CYCLASE TYPE 10, GLYCEROL | Authors: | Kleinboelting, S, Moniot, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-14 | Release date: | 2014-03-05 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLK
| Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLL
| Crystal structure of human soluble Adenylyl Cyclase in complex with bicarbonate | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, BICARBONATE ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLP
| Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLS
| Crystal structure of human soluble Adenylyl Cyclase with Pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLT
| Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLU
| Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLW
| Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate soaked with bisulfite | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLY
| Crystal structure of human soluble Adenylyl Cyclase soaked with biselenite | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, BISELENITE ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLZ
| Crystal structure of human soluble Adenylyl Cyclase with Inhibitor 4, 4'-Diisothiocyano-2,2'-stilbenedisulfonic acid | Descriptor: | 1,2-ETHANEDIOL, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ACETATE ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CM0
| Crystal structure of human soluble Adenylyl Cyclase with alpha,beta- methyleneadenosine-5'-triphosphate soaked with bicarbonate | Descriptor: | CALCIUM ION, CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CM2
| Crystal structure of human soluble Adenylyl Cyclase soaked with bisulfite | Descriptor: | ADENYLATE CYCLASE TYPE 10, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4NI2
| Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase | Descriptor: | 1,2-ETHANEDIOL, Guanylate cyclase soluble subunit alpha-3, Guanylate cyclase soluble subunit beta-1 | Authors: | Seeger, F, Williams, G.J, Tainer, J.A, Garcin, E.D. | Deposit date: | 2013-11-05 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry, 53, 2014
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