7DNY
| Cryo-EM structure of the human ABCB6 (coproporphyrin III-bound) | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Kim, S, Lee, S.S, Park, J.G, Kim, J.W, Kim, S, Kim, N.J, Hong, S, Kang, J.Y, Jin, M.S. | Deposit date: | 2020-12-11 | Release date: | 2022-06-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6. Mol.Cells, 45, 2022
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7BCW
| Structure of MsbA in Salipro with ADP vanadate | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent lipid A-core flippase, ... | Authors: | Traore, D.A.K, Tidow, H. | Deposit date: | 2020-12-21 | Release date: | 2022-01-12 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. Febs J., 289, 2022
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7DQV
| Crystal structure of a CmABCB1 mutant | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, MAGNESIUM ION, NITRATE ION, ... | Authors: | Matsuoka, K, Nakatsu, T, Kato, H. | Deposit date: | 2020-12-24 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3. Protein Sci., 30, 2021
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7BG4
| Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA, ... | Authors: | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | Deposit date: | 2021-01-05 | Release date: | 2022-01-12 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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7LB8
| Structure of a ferrichrome importer FhuCDB from E. coli | Descriptor: | Iron(3+)-hydroxamate import ATP-binding protein FhuC, Iron(3+)-hydroxamate import system permease protein FhuB, Iron(3+)-hydroxamate-binding protein FhuD | Authors: | Hu, W, Zheng, H. | Deposit date: | 2021-01-07 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer. Commun Biol, 4, 2021
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7DV5
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7NDF
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7E1A
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7LKP
| Structure of ATP-free human ABCA4 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Liu, F, Lee, J, Chen, J. | Deposit date: | 2021-02-02 | Release date: | 2021-03-03 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Molecular structures of the eukaryotic retinal importer ABCA4. Elife, 10, 2021
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7LKZ
| Structure of ATP-bound human ABCA4 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Liu, F, Lee, J, Chen, J. | Deposit date: | 2021-02-03 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Molecular structures of the eukaryotic retinal importer ABCA4. Elife, 10, 2021
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7NEQ
| Structure of tariquidar-bound ABCG2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | Authors: | Kowal, J, Locher, K. | Deposit date: | 2021-02-04 | Release date: | 2021-04-21 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NEZ
| Structure of topotecan-bound ABCG2 | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | Authors: | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | Deposit date: | 2021-02-05 | Release date: | 2021-04-21 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NFD
| Structure of mitoxantrone-bound ABCG2 | Descriptor: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | Authors: | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | Deposit date: | 2021-02-06 | Release date: | 2021-04-21 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NHL
| VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Crowe-McAuliffe, C, Murina, V, Hauryliuk, V, Wilson, D.N. | Deposit date: | 2021-02-10 | Release date: | 2021-05-05 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. Nat Commun, 12, 2021
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7NHN
| VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Crowe-McAuliffe, C, Turnbull, K.J, Hauryliuk, V, Wilson, D.N. | Deposit date: | 2021-02-10 | Release date: | 2021-05-05 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. Nat Commun, 12, 2021
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7NIU
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7NIV
| Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-02-14 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIW
| Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation) | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-02-14 | Release date: | 2021-08-25 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NNU
| Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs | Descriptor: | Conserved hypothetical membrane protein, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2021-02-25 | Release date: | 2021-08-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NNT
| Cryo-EM structure of the folate-specific ECF transporter complex in DDM micelles | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2021-02-25 | Release date: | 2021-08-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM. Proc.Natl.Acad.Sci.USA, 118, 2021
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7E7I
| Cryo-EM structure of human ABCA4 in the apo state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7E7Q
| Cryo-EM structure of human ABCA4 in ATP-bound state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7E7O
| Cryo-EM structure of human ABCA4 in NRPE-bound state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7M1P
| Human ABCA4 structure in the unbound state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Scortecci, J.F, Van Petegem, F, Molday, R.S. | Deposit date: | 2021-03-14 | Release date: | 2021-09-08 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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7M1Q
| Human ABCA4 structure in complex with N-ret-PE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Scortecci, J.F, Van Petegem, F, Molday, R.S. | Deposit date: | 2021-03-14 | Release date: | 2021-09-08 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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