7M1P

Human ABCA4 structure in the unbound state

Summary for 7M1P

• Entry DOI: 10.2210/pdb7m1p/pdb
• EMDB information: 23617
• Descriptor: Retinal-specific phospholipid-transporting ATPase ABCA4, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: abc transporter, importer, membrane protein, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 258787.92

Authors

Scortecci, J.F.,Van Petegem, F.,Molday, R.S. (deposition date: 2021-03-14, release date: 2021-09-08, Last modification date: 2021-10-20)

• Primary citation: Scortecci, J.F.,Molday, L.L.,Curtis, S.B.,Garces, F.A.,Panwar, P.,Van Petegem, F.,Molday, R.S.; Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.; Nat Commun, 12:5902-5902, 2021; PubMed: 34625547; DOI: 10.1038/s41467-021-26161-7

Experimental method

ELECTRON MICROSCOPY (3.6 Å)