7NPR
| Structure of an intact ESX-5 inner membrane complex, Composite C3 model | Descriptor: | ESX-5 secretion system ATPase EccB5, ESX-5 secretion system protein EccC5, ESX-5 secretion system protein EccD5, ... | Authors: | Fahrenkamp, D, Bunduc, C.M, Wald, J, Ummels, R, Bitter, W, Houben, E.N.G, Marlovits, T.C. | Deposit date: | 2021-02-28 | Release date: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structure and dynamics of a mycobacterial type VII secretion system. Nature, 593, 2021
|
|
5OCA
| PCSK9:Fab Complex with Dextran Sulfate | Descriptor: | 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... | Authors: | Thirup, S.S, Vilstrup, J.P. | Deposit date: | 2017-06-30 | Release date: | 2017-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun, 8, 2017
|
|
4K8R
| |
7BJ3
| ScpA from Streptococcus pyogenes, S512A active site mutant | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, C5a peptidase, CALCIUM ION, ... | Authors: | Kagawa, T.F, O'Connell, M.R, Cooney, J.C. | Deposit date: | 2021-01-13 | Release date: | 2021-05-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. Comput Struct Biotechnol J, 19, 2021
|
|
7EDD
| |
7YZX
| ScpA from Streptococcus pyogenes, D783A mutant. | Descriptor: | C5a peptidase, CALCIUM ION, MALONIC ACID, ... | Authors: | Kagawa, T.F, Cooney, J.C, Jain, M. | Deposit date: | 2022-02-21 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray diffraction data for the C5a-peptidase mutant with modified activity and specificity. Data Brief, 46, 2023
|
|
4OMD
| |
1CSE
| |
4YN3
| Crystal structure of Cucumisin complex with pro-peptide | Descriptor: | CHLORIDE ION, Cucumisin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Murayama, K, Kato-Murayama, M, Yokoyama, S, Arima, K, Shirouzu, M. | Deposit date: | 2015-03-09 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of cucumisin protease activity regulation by its propeptide J. Biochem., 161, 2017
|
|
4Z2A
| Crystal structure of unglycosylated apo human furin @1.89A | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Furin, ... | Authors: | Gampe, R.T, Pearce, K, Reid, R. | Deposit date: | 2015-03-29 | Release date: | 2016-05-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | BacMam production and crystal structure of nonglycosylated apo human furin at 1.89A resolution Acta Crystallogr.,Sect.F, 2019
|
|
4ZOQ
| Crystal Structure of a Lanthipeptide Protease | Descriptor: | Intracellular serine protease | Authors: | Dong, S.H, Nair, S.K. | Deposit date: | 2015-05-06 | Release date: | 2016-03-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chem Sci, 6, 2015
|
|
5MIM
| Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n | Descriptor: | 1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidine, CALCIUM ION, CHLORIDE ION, ... | Authors: | Dahms, S.O, Guan-Sheng, J, Than, M.E. | Deposit date: | 2016-11-28 | Release date: | 2017-05-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. ACS Chem. Biol., 12, 2017
|
|
5FFN
| Complex of subtilase SubTY from Bacillus sp. TY145 with chymotrypsin inhibitor CI2A | Descriptor: | CALCIUM ION, Enzyme subtilase SubTY from Bacillus sp. TY145, SODIUM ION, ... | Authors: | McAuley, K.E, Svendsen, A, Oestergaard, P.R, Dohnalek, J, Wilson, K.S. | Deposit date: | 2015-12-18 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Stabilization of Enzymes by Metal Binding: Structures of Two Alkalophilic Bacillus Subtilases and Analysis of the Second Metal-Binding Site of the Subtilase Family Book, 2016
|
|
5FAX
| |
4TR2
| Crystal structure of PvSUB1 | Descriptor: | CALCIUM ION, PHOSPHATE ION, Subtilisin-like 1 serine protease | Authors: | Giganti, D, Bouillon, A, Martinez, M, Weber, P, Girard-Blanc, C, Petres, S, Haouz, A, Barale, J.C, Alzari, P.M. | Deposit date: | 2014-06-13 | Release date: | 2014-09-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase. Nat Commun, 5, 2014
|
|
5FBZ
| Structure of subtilase SubHal from Bacillus halmapalus - complex with chymotrypsin inhibitor CI2A | Descriptor: | Autoproteolytic fragment of enzyme subtilase SubHal, CALCIUM ION, Enzyme subtilase SubHal from Bacillus halmapalus, ... | Authors: | Dohnalek, J, Brzozowski, A.M, Svendsen, A, Wilson, K.S. | Deposit date: | 2015-12-14 | Release date: | 2016-05-18 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Stabilization of Enzymes by Metal Binding: Structures of Two Alkalophilic Bacillus Subtilases and Analysis of the Second Metal-Binding Site of the Subtilase Family Book, 2016
|
|
4RYD
| |
1LW6
| |
8AXG
| Crystal structure of Fusobacterium nucleatum fusolisin protease | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fusolisin, ... | Authors: | Isupov, M.N, Wiener, R, Rouvinski, A, Fahoum, J, Kumar, M, Read, R.J. | Deposit date: | 2022-08-31 | Release date: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal structure of Fusobacterium nucleatum fusolisin protease To Be Published
|
|
8B4V
| X-ray structure of furin (PCSK3) in complex with benzamidine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CALCIUM ION, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
|
|
8B4W
| X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine | Descriptor: | 1H-isoindol-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
|
|
8B4X
| X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol | Descriptor: | CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
|
|
8BTY
| Structure of the active form of ScpB, the C5a-peptidase from Streptococcus agalactiae. | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, C5a peptidase, CALCIUM ION, ... | Authors: | Kagawa, T.F, Cooney, J.C, Miclot, T, Cullen, R. | Deposit date: | 2022-11-30 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.7 angstrom crystal structure of the C5a peptidase from Streptococcus agalactiae (ScpB) reveals an active site competent for catalysis. Proteins, 92, 2024
|
|
1MEE
| THE COMPLEX BETWEEN THE SUBTILISIN FROM A MESOPHILIC BACTERIUM AND THE LEECH INHIBITOR EGLIN-C | Descriptor: | CALCIUM ION, EGLIN C, MESENTERICOPEPTIDASE | Authors: | Dauter, Z, Betzel, C, Wilson, K.S. | Deposit date: | 1991-04-15 | Release date: | 1992-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Complex between the subtilisin from a mesophilic bacterium and the leech inhibitor eglin-C. Acta Crystallogr.,Sect.B, 47, 1991
|
|
2SEC
| |