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8TL2	CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... Authors: Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. Deposit date: 2023-07-26 Release date: 2024-08-28 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques. To Be Published
8TL3	CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP glycoprotein gp120, ... Authors: Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. Deposit date: 2023-07-26 Release date: 2024-08-28 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques. To Be Published
8TL4	CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... Authors: Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. Deposit date: 2023-07-26 Release date: 2024-08-28 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques. To Be Published
8TL5	CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... Authors: Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. Deposit date: 2023-07-26 Release date: 2024-08-28 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques. To Be Published
8TNG	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site targeting nanobody R27, ... Authors: Zhou, T, Kwong, P.D, Xu, J. Deposit date: 2023-08-01 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site To Be Published
8TNH	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site nanobody G36, ... Authors: Zhou, T, Kwong, P.D, Xu, J. Deposit date: 2023-08-01 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site To Be Published
8TNI	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ... Authors: Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J. Deposit date: 2023-08-01 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex To Be Published
8TNU	Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... Authors: Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D. Deposit date: 2023-08-02 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques To Be Published
8TO7	Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HERH-b*01 heavy chain, ... Authors: Roark, R.S, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L.S, Kwong, P.D. Deposit date: 2023-08-03 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques To Be Published
8TOP	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP glycoprotein gp41, ... Authors: Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D. Deposit date: 2023-08-03 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide To Be Published
8TOX	Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Wang, S, Kwong, P.D. Deposit date: 2023-08-04 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab To Be Published
8TQ1	HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bovine Bess4 Fab heavy chain, ... Authors: Ozorowski, G, Lee, W.H, Ward, A.B. Deposit date: 2023-08-06 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Immunization of cows with HIV Envelope trimers generates broadly neutralizing antibodies to the V2-apex as well as the CD4 binding site from the ultra-long CDRH3 repertoire To Be Published
8TR3	Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CNE40 SOSIP Envelope glycoprotein gp120, ... Authors: Chan, K.-W, Kong, X.P. Deposit date: 2023-08-09 Release date: 2024-06-19 Method: ELECTRON MICROSCOPY (3.74 Å) Cite: Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun, 15, 2024
8TTW	Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Tolbert, W.D, Pozharski, E, Pazgier, M. Deposit date: 2023-08-15 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
8VFV	HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B16_d77.5 mouse Fab heavy chain Fv, ... Authors: Ozorowski, G, Torres, J.L, Ward, A.B. Deposit date: 2023-12-22 Release date: 2024-05-15 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. Science, 384, 2024
9BER	Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2024-04-16 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation. Cell Rep, 43, 2024
9BF6	Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, Envelope glycoprotein gp41, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2024-04-16 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation. Cell Rep, 43, 2024

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