8VFV

HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab

This is a non-PDB format compatible entry.

Summary for 8VFV

• Entry DOI: 10.2210/pdb8vfv/pdb
• EMDB information: 43190
• Descriptor: RM20A3 Fab heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, RM20A3 Fab light chain, ... (10 entities in total)
• Functional Keywords: mouse antibody, germline targeting, hiv-1, vaccine design, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Macaca mulatta (Rhesus monkey); More
• Total number of polymer chains: 14
• Total formula weight: 335814.31

Authors

Ozorowski, G.,Torres, J.L.,Ward, A.B. (deposition date: 2023-12-22, release date: 2024-05-15, Last modification date: 2024-06-05)

• Primary citation: Xie, Z.,Lin, Y.C.,Steichen, J.M.,Ozorowski, G.,Kratochvil, S.,Ray, R.,Torres, J.L.,Liguori, A.,Kalyuzhniy, O.,Wang, X.,Warner, J.E.,Weldon, S.R.,Dale, G.A.,Kirsch, K.H.,Nair, U.,Baboo, S.,Georgeson, E.,Adachi, Y.,Kubitz, M.,Jackson, A.M.,Richey, S.T.,Volk, R.M.,Lee, J.H.,Diedrich, J.K.,Prum, T.,Falcone, S.,Himansu, S.,Carfi, A.,Yates 3rd, J.R.,Paulson, J.C.,Sok, D.,Ward, A.B.,Schief, W.R.,Batista, F.D.; mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies.; Science, 384:eadk0582-eadk0582, 2024; PubMed: 38753770; DOI: 10.1126/science.adk0582

Experimental method

ELECTRON MICROSCOPY (3.3 Å)