6ZP4
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![BU of 6zp4 by Molmil](/molmil-images/mine/6zp4) | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-07-08 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
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7A5G
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![BU of 7a5g by Molmil](/molmil-images/mine/7a5g) | Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA | Descriptor: | 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ... | Authors: | Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V. | Deposit date: | 2020-08-21 | Release date: | 2020-12-23 | Method: | ELECTRON MICROSCOPY (4.33 Å) | Cite: | Elongational stalling activates mitoribosome-associated quality control. Science, 370, 2020
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7A5K
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![BU of 7a5k by Molmil](/molmil-images/mine/7a5k) | Structure of the human mitoribosome in the post translocation state bound to mtEF-G1 | Descriptor: | 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ... | Authors: | Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V. | Deposit date: | 2020-08-21 | Release date: | 2020-12-23 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Elongational stalling activates mitoribosome-associated quality control. Science, 370, 2020
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7ABF
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![BU of 7abf by Molmil](/molmil-images/mine/7abf) | Human pre-Bact-1 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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6ZMO
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![BU of 6zmo by Molmil](/molmil-images/mine/6zmo) | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-07-03 | Release date: | 2020-08-19 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
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8K2D
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![BU of 8k2d by Molmil](/molmil-images/mine/8k2d) | Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A | Descriptor: | 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Buschauer, R, Beckmann, R, Cheng, J. | Deposit date: | 2023-07-12 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8OZ0
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![BU of 8oz0 by Molmil](/molmil-images/mine/8oz0) | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Fraser, C.S, Ramakrishnan, V. | Deposit date: | 2023-05-06 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat.Struct.Mol.Biol., 31, 2024
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8I0V
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![BU of 8i0v by Molmil](/molmil-images/mine/8i0v) | The cryo-EM structure of human post-Bact complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0P
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![BU of 8i0p by Molmil](/molmil-images/mine/8i0p) | The cryo-EM structure of human pre-Bact complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0W
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![BU of 8i0w by Molmil](/molmil-images/mine/8i0w) | The cryo-EM structure of human C complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Coiled-coil domain-containing protein 94, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0R
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![BU of 8i0r by Molmil](/molmil-images/mine/8i0r) | The cryo-EM structure of human Bact-I complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0U
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![BU of 8i0u by Molmil](/molmil-images/mine/8i0u) | The cryo-EM structure of human Bact-IV complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0T
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![BU of 8i0t by Molmil](/molmil-images/mine/8i0t) | The cryo-EM structure of human Bact-III complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8I0S
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![BU of 8i0s by Molmil](/molmil-images/mine/8i0s) | The cryo-EM structure of human Bact-II complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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8P2F
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![BU of 8p2f by Molmil](/molmil-images/mine/8p2f) | Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state | Descriptor: | 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 2-[(3~{R},4~{S},5~{S},8~{S},9~{S},10~{S},11~{R},13~{S},14~{S},16~{S})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid, ... | Authors: | Gonzalez-Lopez, A, Selmer, M. | Deposit date: | 2023-05-16 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane. Sci Rep, 14, 2024
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8P2G
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![BU of 8p2g by Molmil](/molmil-images/mine/8p2g) | Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state | Descriptor: | 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 2-[(3~{R},4~{S},5~{S},8~{S},9~{S},10~{S},11~{R},13~{S},14~{S},16~{S})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid, ... | Authors: | Gonzalez-Lopez, A, Selmer, M. | Deposit date: | 2023-05-16 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.02 Å) | Cite: | Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane. Sci Rep, 14, 2024
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8P2H
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![BU of 8p2h by Molmil](/molmil-images/mine/8p2h) | |
4V9J
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![BU of 4v9j by Molmil](/molmil-images/mine/4v9j) | 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | Deposit date: | 2013-04-23 | Release date: | 2014-07-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.86 Å) | Cite: | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science, 340, 2013
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4V5M
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![BU of 4v5m by Molmil](/molmil-images/mine/4v5m) | tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE) | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T. | Deposit date: | 2010-10-01 | Release date: | 2014-07-09 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites. Nature, 468, 2010
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4V85
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![BU of 4v85 by Molmil](/molmil-images/mine/4v85) | Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhou, J, Lancaster, L, Trakhanov, S, Noller, H.F. | Deposit date: | 2011-06-13 | Release date: | 2014-07-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. Rna, 18, 2012
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4V9H
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![BU of 4v9h by Molmil](/molmil-images/mine/4v9h) | Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Tourigny, D.S, Fernandez, I.S, Kelley, A.C, Ramakrishnan, V. | Deposit date: | 2013-03-25 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (2.857 Å) | Cite: | Elongation factor G bound to the ribosome in an intermediate state of translocation. Science, 340, 2013
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4V5R
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![BU of 4v5r by Molmil](/molmil-images/mine/4v5r) | The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome. | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | Deposit date: | 2010-12-07 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding. Nat.Struct.Mol.Biol., 18, 2011
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4V89
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![BU of 4v89 by Molmil](/molmil-images/mine/4v89) | Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome (without viomycin) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhou, J, Lancaster, L, Trakhanov, S, Noller, H.F. | Deposit date: | 2011-11-17 | Release date: | 2014-07-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. Rna, 18, 2012
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4V8U
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![BU of 4v8u by Molmil](/molmil-images/mine/4v8u) | Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex. | Descriptor: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Gao, Y.G, Feng, S, Chen, Y. | Deposit date: | 2012-08-28 | Release date: | 2014-07-09 | Last modified: | 2019-10-30 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal structure of 70S ribosome with both cognate tRNAs in the E and P sites representing an authentic elongation complex. PLoS ONE, 8, 2013
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4V9M
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![BU of 4v9m by Molmil](/molmil-images/mine/4v9m) | 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state. | Descriptor: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | Deposit date: | 2013-04-25 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science, 340, 2013
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