1XG5
 
 | | Structure of human putative dehydrogenase MGC4172 in complex with NADP | | Descriptor: | ACETIC ACID, ARPG836, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Kavanagh, K, Ng, S, Sharma, S, Vedadi, M, von Delft, F, Walker, J.R, dhe Paganon, S, Bray, J, Oppermann, U, Edwards, A, Arrowsmith, C, Sundstrom, M, Structural Genomics Consortium (SGC) | | Deposit date: | 2004-09-16 | | Release date: | 2004-10-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Structural Genomics Consortium: Structure of the putative human dehydrogenase MGC4172
To be Published
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1XR3
 | | Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound | | Descriptor: | 4-(DIAZENYLCARBONYL)PYRIDINE, ACTINORHODIN POLYKETIDE KETOREDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Korman, T.P, Hill, J.A, Vu, T.N, Tsai, S.C. | | Deposit date: | 2004-10-13 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
Biochemistry, 43, 2004
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1XSE
 | | Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 | | Descriptor: | 11beta-hydroxysteroid dehydrogenase type 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Ogg, D, Elleby, B, Norstrom, C, Stefansson, K, Abrahmsen, L, Oppermann, U, Svensson, S. | | Deposit date: | 2004-10-19 | | Release date: | 2004-11-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
J.Biol.Chem., 280, 2005
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1XU7
 | | Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1 | | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ... | | Authors: | Hosfield, D.J, Wu, Y, Skene, R.J, Hilger, M, Jennings, A, Snell, G.P, Aertgeerts, K. | | Deposit date: | 2004-10-25 | | Release date: | 2004-11-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
J.Biol.Chem., 280, 2005
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1XU9
 | | Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Corticosteroid 11-beta-dehydrogenase, ... | | Authors: | Hosfield, D.J, Wu, Y, Skene, R.J, Hilger, M, Jennings, A, Snell, G.P, Aertgeerts, K. | | Deposit date: | 2004-10-25 | | Release date: | 2004-11-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
J.Biol.Chem., 280, 2005
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1Y5R
 | | The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone | | Descriptor: | CORTICOSTERONE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ... | | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S. | | Deposit date: | 2004-12-02 | | Release date: | 2005-05-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
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1Y5M
 | | The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes | | Descriptor: | Corticosteroid 11-beta-dehydrogenase, isozyme 1, N-OCTANE, ... | | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.R. | | Deposit date: | 2004-12-02 | | Release date: | 2005-05-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
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1YB1
 | | Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI | | Descriptor: | 17-beta-hydroxysteroid dehydrogenase type XI, Androsterone, CHLORIDE ION, ... | | Authors: | Lukacik, P, Bunkoczi, G, Kavanagh, K, Ng, S, von Delft, F, Bray, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2004-12-18 | | Release date: | 2004-12-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.
To be Published
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1YO6
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1ZEM
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1Z6Z
 | | Crystal Structure of Human Sepiapterin Reductase in complex with NADP+ | | Descriptor: | CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | | Authors: | Ugochukwu, E, Kavanagh, K, Ng, S, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-03-23 | | Release date: | 2005-04-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of Human Sepiapterin Reductase
To be Published
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8G93
 | | Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | | Descriptor: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Liu, S. | | Deposit date: | 2023-02-21 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8G9V
 | | Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | | Descriptor: | 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Liu, S. | | Deposit date: | 2023-02-22 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.645 Å) | | Cite: | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8G84
 | | Crystal structures of HSD17B13 complexes | | Descriptor: | Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Liu, S. | | Deposit date: | 2023-02-17 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.467 Å) | | Cite: | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8G89
 | | HSD17B13 in complex with cofactor and inhibitor | | Descriptor: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Liu, S. | | Deposit date: | 2023-02-17 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.222 Å) | | Cite: | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8I70
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8I6Z
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8J2D
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8HJW
 | | Bi-functional malonyl-CoA reductuase from Chloroflexus aurantiacus | | Descriptor: | Short-chain dehydrogenase/reductase SDR | | Authors: | Ahn, J.W, Kim, S. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity.
Int.J.Biol.Macromol., 242, 2023
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8HI5
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8HI4
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8HI6
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8J2C
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8J29
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8J2E
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