9G9W
 
 | |
5WSK
 
 | |
5TAV
 
 | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 4) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | Deposit date: | 2016-09-10 | Release date: | 2016-10-12 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
|
|
9G9V
 
 | |
8JPB
 
 | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
|
|
7VC1
 
 | Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95 and L-proline in space group P21 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Yogavel, M, Malhotra, N, Sharma, A. | Deposit date: | 2021-09-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
|
|
4Z93
 
 | BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18. | Descriptor: | 1,2-ETHANEDIOL, 1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indole, Bromodomain-containing protein 4 | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2015-04-09 | Release date: | 2015-07-01 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Structure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J.Med.Chem., 58, 2015
|
|
9DDE
 
 | ncPRC1RYBP bound to H2AK119Ub/H1.4 chromatosome | Descriptor: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H1.4, ... | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | Deposit date: | 2024-08-28 | Release date: | 2024-11-20 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1. Nature, 636, 2024
|
|
7SCJ
 
 | |
6U4Q
 
 | Carbonic anhydrase 2 in complex with SB4197 | Descriptor: | 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase 2, ZINC ION | Authors: | Murray, A.B, Lomelino, C.L, McKenna, R. | Deposit date: | 2019-08-26 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.306 Å) | Cite: | "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63, 2020
|
|
5T50
 
 | LIGAND-FREE LECTIN FROM BAUHINIA FORFICATA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Lectin | Authors: | Lubkowski, J, Wlodawer, A. | Deposit date: | 2016-08-30 | Release date: | 2016-12-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth. FEBS J., 284, 2017
|
|
6BFV
 
 | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 5-fluoro-1,2-dihydropyrimidin-2-one | Descriptor: | 5-fluoropyrimidin-2-ol, DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase | Authors: | Faheem, M, Neto, J.B, Collins, P, Pearce, N.M, Valadares, N.F, Bird, L, Pereira, H.M, Delft, F.V, Barbosa, J.A.R.G. | Deposit date: | 2017-10-27 | Release date: | 2018-11-07 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.921 Å) | Cite: | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 5-fluoropyrimidin-1-ium-2-olate To Be Published
|
|
9DBY
 
 | ncPRC1RYBP bound to singly modified H2AK119Ub nucleosome | Descriptor: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H2A type 1, ... | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | Deposit date: | 2024-08-24 | Release date: | 2024-11-20 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1. Nature, 636, 2024
|
|
1U27
 
 | Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4 | Descriptor: | Cytohesin 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
|
|
5TAQ
 
 | Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 3&4) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | Deposit date: | 2016-09-10 | Release date: | 2016-10-12 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
|
|
9GHY
 
 | Cyclophilin A in complex with Sanglifehrin A analogue (2R,3S,7S,10S,E)-10-(3-aminopropyl)-2,7-dimethylspiro[3,8,11-triaza-1(2,7)-quinolina-5(3,1)-pyridazinacyclopentadecaphanene-13,5'-[1,3]dioxan]-14-ene-4,6,9,12-tetraone | Descriptor: | (2R,3S,7S,10S,E)-10-(3-aminopropyl)-2,7-dimethylspiro[3,8,11-triaza-1(2,7)-quinolina-5(3,1)-pyridazinacyclopentadecaphanene-13,5'-[1,3]dioxan]-14-ene-4,6,9,12-tetraone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A | Authors: | Meyners, C, Dreizler, J.K, Hausch, F. | Deposit date: | 2024-08-16 | Release date: | 2024-11-06 | Last modified: | 2024-12-04 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Toward Dual Targeting of Catalytic and Gatekeeper Pockets in Cyclophilins Using a Macrocyclic Scaffold. Acs Med.Chem.Lett., 15, 2024
|
|
7BG6
 
 | HRV14 native particle solved by cryoEM | Descriptor: | Genome polyprotein, RNA-octamer (5'-R(P*UP*GP*UP*UP*UP*UP*UP*A)-3') | Authors: | Hrebik, D, Fuzik, T, Plevka, P. | Deposit date: | 2021-01-06 | Release date: | 2021-05-19 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | ICAM-1 induced rearrangements of capsid and genome prime rhinovirus 14 for activation and uncoating. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5SXH
 
 | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | Descriptor: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | Authors: | Shi, K, Kurahashi, K, Aihara, H. | Deposit date: | 2016-08-09 | Release date: | 2017-12-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Sci Rep, 7, 2017
|
|
9BH5
 
 | High-resolution C. elegans 80S ribosome structure - class 1 | Descriptor: | 18S rRNA, 28S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Sehgal, E, Serrao, V.H.B, Arribere, J. | Deposit date: | 2024-04-19 | Release date: | 2024-09-04 | Last modified: | 2024-11-13 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity. Rna, 30, 2024
|
|
9CAI
 
 | High-resolution C. elegans 80S ribosome structure - class 1 | Descriptor: | 18S rRNA, 28S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Sehgal, E, Serrao, V.H.B, Arribere, J. | Deposit date: | 2024-06-17 | Release date: | 2024-09-11 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity. Rna, 30, 2024
|
|
6R02
 
 | Psychrobacter arcticus ATP phosphoribosyltransferase bound to histidine and PRPP | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, ... | Authors: | Alphey, M.S, da Silva, R.G, Thomson, C.M. | Deposit date: | 2019-03-12 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine. Biochemistry, 58, 2019
|
|
5TAP
 
 | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, all particles) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | Deposit date: | 2016-09-10 | Release date: | 2016-10-12 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
|
|
9GWO
 
 | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 54571126 | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | Deposit date: | 2024-09-27 | Release date: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders To Be Published
|
|
2R5Q
 
 | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir | Descriptor: | 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE, Protease | Authors: | Coman, R.M, Robbins, A.H, McKenna, R, Dunn, B.M. | Deposit date: | 2007-09-04 | Release date: | 2007-11-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Contribution of Naturally Occurring Polymorphisms in Altering the Biochemical and Structural Characteristics of HIV-1 Subtype C Protease Biochemistry, 47, 2008
|
|
6BI1
 
 | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (2R)-2-amino-3-(benzyloxy)propan-1-ol | Descriptor: | DIMETHYL SULFOXIDE, O-benzyl-L-serine, Purine nucleoside phosphorylase | Authors: | Faheem, M, Neto, J.B, Collins, P, Pearce, N.M, Valadares, N.F, Bird, L, Pereira, H.M, Delft, F.V, Barbosa, J.A.R.G. | Deposit date: | 2017-10-31 | Release date: | 2018-11-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (2R)-2-amino-3-(benzyloxy)propan-1-ol To Be Published
|
|