4Z93

BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18.

Summary for 4Z93

Entry DOI	10.2210/pdb4z93/pdb
Descriptor	Bromodomain-containing protein 4, 1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indole, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	13734.99
Authors	Meagher, J.L.,Stuckey, J.A. (deposition date: 2015-04-09, release date: 2015-07-01, Last modification date: 2023-09-27)
Primary citation	Ran, X.,Zhao, Y.,Liu, L.,Bai, L.,Yang, C.Y.,Zhou, B.,Meagher, J.L.,Chinnaswamy, K.,Stuckey, J.A.,Wang, S. Structure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J.Med.Chem., 58:4927-4939, 2015 Cited by PubMed: 26080064 DOI: 10.1021/acs.jmedchem.5b00613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.27 Å)

Structure validation