4Z93
BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 4LD A 501 |
| Chain | Residue |
| A | TRP374 |
| A | HOH604 |
| A | HOH643 |
| A | HOH652 |
| A | PRO375 |
| A | PHE376 |
| A | LEU385 |
| A | LEU387 |
| A | CYS429 |
| A | ASN433 |
| A | HIS437 |
| A | VAL439 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | TYR430 |
| A | ARG444 |
| A | GLN447 |
| A | GLN447 |
| A | ASP448 |
| A | HOH673 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331 |
| Chain | Residue | Details |
| A | ASN433 |
