6U4Q

Carbonic anhydrase 2 in complex with SB4197

Summary for 6U4Q

Entry DOI	10.2210/pdb6u4q/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, ... (4 entities in total)
Functional Keywords	inhibitor, complex, cyclical sulfonamide, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29210.28
Authors	Murray, A.B.,Lomelino, C.L.,McKenna, R. (deposition date: 2019-08-26, release date: 2020-01-22, Last modification date: 2023-10-11)
Primary citation	Bua, S.,Lomelino, C.,Murray, A.B.,Osman, S.M.,ALOthman, Z.A.,Bozdag, M.,Abdel-Aziz, H.A.,Eldehna, W.M.,McKenna, R.,Nocentini, A.,Supuran, C.T. "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63:321-333, 2020 Cited by PubMed: 31794211 DOI: 10.1021/acs.jmedchem.9b01669 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.306 Å)

Structure validation