4KU1
| Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering | Descriptor: | Ig gamma-1 chain C region, TETRAETHYLENE GLYCOL, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Frank, M, Walker, R, Lanzilotta, W.N, Prestegard, J.H, Barb, A.W. | Deposit date: | 2013-05-21 | Release date: | 2014-02-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Immunoglobulin g1 fc domain motions: implications for fc engineering. J.Mol.Biol., 426, 2014
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4L9Q
| X-ray study of human serum albumin complexed with teniposide | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside, SERUM ALBUMIN | Authors: | Wang, Z, Ho, J.X, Ruble, J, Rose, J.P, Carter, D.C. | Deposit date: | 2013-06-18 | Release date: | 2013-07-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim.Biophys.Acta, 1830, 2013
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5US5
| Solution structure of the IreB homodimer | Descriptor: | UPF0297 protein EF_1202 | Authors: | Lytle, B.L, Peterson, F.C, Volkman, B.F, Kristich, C.J, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2017-02-13 | Release date: | 2017-06-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and Dimerization of IreB, a Negative Regulator of Cephalosporin Resistance in Enterococcus faecalis. J. Mol. Biol., 429, 2017
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4LA0
| X-ray study of human serum albumin complexed with bicalutamide | Descriptor: | R-BICALUTAMIDE, SERUM ALBUMIN | Authors: | Wang, Z, Ho, J.X, Ruble, J, Rose, J.P, Carter, D.C. | Deposit date: | 2013-06-18 | Release date: | 2013-07-24 | Last modified: | 2014-02-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim.Biophys.Acta, 1830, 2013
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2XKX
| Single particle analysis of PSD-95 in negative stain | Descriptor: | DISKS LARGE HOMOLOG 4 | Authors: | Fomina, S, Howard, T.D, Sleator, O.K, Golovanova, M, O'Ryan, L, Leyland, M.L, Grossmann, J.G, Collins, R.F, Prince, S.M. | Deposit date: | 2010-07-15 | Release date: | 2011-07-20 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (22.9 Å), SOLUTION SCATTERING | Cite: | Self-Directed Assembly and Clustering of the Cytoplasmic Domains of Inwardly Rectifying Kir2.1 Potassium Channels on Association with Psd-95 Biochim.Biophys.Acta, 1808, 2011
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4LFI
| Crystal structure of scCK2 alpha in complex with GMPPNP | Descriptor: | Casein kinase II subunit alpha, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Liu, H. | Deposit date: | 2013-06-27 | Release date: | 2014-03-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D, 70, 2014
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4LEN
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3QBC
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3S5J
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8TMT
| Crystal structure of KPC-44 carbapenemase in complex with vaborbactam | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, LITHIUM ION, ... | Authors: | Sun, Z, Palzkill, T, Hu, L, Neetu, N, Lin, H, Sankaran, B, Wang, J, Prasad, B. | Deposit date: | 2023-07-30 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
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8TN0
| Crystal structure of KPC-44 carbapenemase w/o cryoprotectant | Descriptor: | SULFATE ION, beta-lactamase | Authors: | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | Deposit date: | 2023-07-31 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
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8TJM
| Crystal structure of KPC-44 carbapenemase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, beta-lactamase | Authors: | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | Deposit date: | 2023-07-23 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
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8TMR
| Crystal structure of KPC-44 carbapenemase complexed with avibactam | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, PHOSPHATE ION, ... | Authors: | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | Deposit date: | 2023-07-30 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
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8TEO
| Shaker in low K+ (4mM K+) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | Authors: | Tan, X, Swartz, K.J. | Deposit date: | 2023-07-06 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse. Sci Adv, 9, 2023
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8TWD
| Structure of IraM-bound RssB | Descriptor: | ACETATE ION, Anti-adapter protein IraM, Regulator of RpoS | Authors: | Brugger, C, Deaconescu, A.M. | Deposit date: | 2023-08-20 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | IraM remodels the RssB segmented helical linker to stabilize sigma s against degradation by ClpXP. J.Biol.Chem., 300, 2023
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8TXY
| X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera | Descriptor: | DI(HYDROXYETHYL)ETHER, N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, SULFATE ION, ... | Authors: | Raymond, D.D, Lemke, C.T, Shaffer, P.L, Collins, B, Steele, R, Seierstad, M. | Deposit date: | 2023-08-24 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U1G
| Prefusion-stabilized SARS-CoV-2 S2 subunit | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2 | Authors: | Hsieh, C.-L, McLellan, J.S. | Deposit date: | 2023-08-31 | Release date: | 2024-01-24 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nat Commun, 15, 2024
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8DRJ
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8DRM
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8DRD
| Ni(II)-bound B2 dimer (H60/H100/H104) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, HEME C, NICKEL (II) ION, ... | Authors: | Choi, T.S, Tezcan, F.A. | Deposit date: | 2022-07-20 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving-Williams Behavior. J.Am.Chem.Soc., 144, 2022
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8UAK
| Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with Darovasertib (NVP-LXS196) at 2.82-A resolution | Descriptor: | (6M)-3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide, Protein kinase C alpha type | Authors: | Romanowski, M.J, Lam, J, Visser, M. | Deposit date: | 2023-09-21 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma. J.Med.Chem., 67, 2024
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8DRL
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8DRF
| Zn(II)-bound B2 dimer (H60/H100/H104) | Descriptor: | HEME C, Soluble cytochrome b562, ZINC ION | Authors: | Choi, T.S, Tezcan, F.A. | Deposit date: | 2022-07-20 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving-Williams Behavior. J.Am.Chem.Soc., 144, 2022
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8TJT
| The Fab fragment of an anti-glucagon receptor (GCGR) antibody | Descriptor: | anti-GCGR Fab heavy chain, anti-GCGR Fab light chain | Authors: | Dai, J, Carter, P.J, Sudhamsu, J, Kung, J. | Deposit date: | 2023-07-24 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG 1 antibody. Mabs, 16, 2024
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8UCH
| Thermophilic RNA Ligase from Palaeococcus pacificus K92A + ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | Authors: | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | Deposit date: | 2023-09-26 | Release date: | 2024-02-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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