4KU1

Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering

Summary for 4KU1

• Entry DOI: 10.2210/pdb4ku1/pdb
• Descriptor: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: human fc fragment, immune response, immune system
• Biological source: HOMO SAPIENS (human)
• Cellular location: Secreted: P01857
• Total number of polymer chains: 2
• Total formula weight: 50876.70

Authors

Frank, M.,Walker, R.,Lanzilotta, W.N.,Prestegard, J.H.,Barb, A.W. (deposition date: 2013-05-21, release date: 2014-02-19, Last modification date: 2020-07-29)

• Primary citation: Frank, M.,Walker, R.C.,Lanzilotta, W.N.,Prestegard, J.H.,Barb, A.W.; Immunoglobulin g1 fc domain motions: implications for fc engineering.; J.Mol.Biol., 426:1799-1811, 2014; PubMed: 24522230; DOI: 10.1016/j.jmb.2014.01.011

Experimental method

X-RAY DIFFRACTION (1.9 Å)