PDB: 1252 resultsInfo pagesStatus searchChemie searchBIRD

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7JZE	Dihydrodipicolinate synthase mutant S48W Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZA	Dihydrodipicolinate synthase S48F mutant with lysine in the allosteric site, and pyruvate and succinic semi-aldehyde in the catalytic site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, LYSINE, ... Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-09-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZ7	Dihydrodipicolinate synthase mutant S48F Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Mapping the unchartered waters of dihydrodipicolinate synthase: a novel mechanism of allosteric inhibition. To Be Published
7JZ8	Dihydrodipicolinate synthase mutant S48F with lysine in the allosteric site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the unchartered waters of dihydrodipicolinate synthase: a novel mechanism of allosteric inhibition. To Be Published
6JCX	Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.903 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
7KWO	rFVIIIFc-VWF-XTEN (BIVV001) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... Authors: Fuller, J.R, Batchelor, J.D. Deposit date: 2020-12-01 Release date: 2021-03-03 Last modified: 2021-06-09 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy. Blood, 137, 2021
7KTR	Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) Descriptor: Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... Authors: Herbst, D.A, Esbin, M.N, Nogales, E. Deposit date: 2020-11-24 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
6HA8	Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Crowe-McAuliffe, C, Graf, M, Huter, P, Abdelshahid, M, Novacek, J, Wilson, D.N. Deposit date: 2018-08-07 Release date: 2018-08-29 Last modified: 2021-01-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HLR	Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused) Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
6HKO	Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-07 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.42 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
6HLS	Yeast apo RNA polymerase I* Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
7K66	Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A9 heavy chain, ... Authors: Childers, K.C, Gish, J, Jarvis, L, Peters, S, Garrels, C, Smith, I.W, Spencer, H.T, Spiegel, P.C. Deposit date: 2020-09-18 Release date: 2020-10-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.92 Å) Cite: Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor. Blood, 137, 2021
6HA1	Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Crowe-McAuliffe, C, Graf, M, Huter, P, Abdelshahid, M, Novacek, J, Wilson, D.N. Deposit date: 2018-08-07 Release date: 2018-08-29 Last modified: 2021-01-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6IPB	Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15 Descriptor: GLYCEROL, L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B15 Authors: Zhang, L, Xie, W, Wang, C. Deposit date: 2018-11-02 Release date: 2020-01-15 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem. Pharmacol., 172, 2019
6HTQ	Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Wilson, D.N, Abdelshahid, M. Deposit date: 2018-10-04 Release date: 2019-10-23 Last modified: 2020-09-30 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel. Cell Rep, 32, 2020
6JCY	Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF sigma factor sigH/E Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
7KBT	Factor VIII in complex with the anti-C2 domain antibody, G99 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C. Deposit date: 2020-10-02 Release date: 2020-11-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (4.15 Å) Cite: Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor Front Immunol, 12, 2021
6HLQ	Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
7JXY	Structure of TTBK1 kinase domain in complex with Compound 18 Descriptor: (3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol, Tau-tubulin kinase 1 Authors: Chodaprambil, J.V. Deposit date: 2020-08-28 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021
7JXX	Structure of TTBK1 kinase domain in complex with Compound 3 Descriptor: 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol, SODIUM ION, Tau-tubulin kinase 1 Authors: Chodaprambil, J.V. Deposit date: 2020-08-28 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021
6JSH	Apo-state Fatty Acid Synthase Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Qiu, S.W, Liu, S. Deposit date: 2019-04-08 Release date: 2019-09-25 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (5.1 Å) Cite: Modulation of fatty acid synthase by ATR checkpoint kinase Rad3. J Mol Cell Biol, 11, 2019
6JSI	Co-purified Fatty Acid Synthase Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Qiu, S.W, Liu, S. Deposit date: 2019-04-08 Release date: 2019-09-25 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Modulation of fatty acid synthase by ATR checkpoint kinase Rad3. J Mol Cell Biol, 11, 2019
6KOP	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 9 nt Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.303 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KOQ	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 10 nt Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.353 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KON	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 5 nt Descriptor: DNA (5'-D(P*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020

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