6IPB

Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15

Summary for 6IPB

• Entry DOI: 10.2210/pdb6ipb/pdb
• Descriptor: UDP-glucuronosyltransferase 2B15, L(+)-TARTARIC ACID, GLYCEROL, ... (4 entities in total)
• Functional Keywords: drug metabolism, ugt, glycosyltransferase, tartaric acid, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 86339.26

Authors

Zhang, L.,Xie, W.,Wang, C. (deposition date: 2018-11-02, release date: 2020-01-15, Last modification date: 2024-03-27)

• Primary citation: Zhang, L.,Zhu, L.,Qu, W.,Wu, F.,Hu, M.,Xie, W.,Liu, Z.,Wang, C.; Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15.; Biochem. Pharmacol., 172:113753-113753, 2019; PubMed: 31837310; DOI: 10.1016/j.bcp.2019.113753

Experimental method

X-RAY DIFFRACTION (1.78 Å)