6IPB

Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	UDP-glucuronosyltransferase 2B15	polymer	191	21342.6	4	UniProt (P54855) Pfam (PF00201)	Homo sapiens (Human)	UDPGT 2B15,HLUG4,UDP-glucuronosyltransferase 2B8,UDPGT 2B8,UDPGTh-3
2	E, G, H, I (A, B, C, D)	L(+)-TARTARIC ACID	non-polymer		150.1	4	Chemie (TLA)
3	F, J, K, L (A, D)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
4	M, N, O, P (A, B, C, D)	water	water		18.0	655	Chemie (HOH)

Sequence modifications

A, B, C, D: 284 - 451 (UniProt: P54855)

PDB	External Database	Details
Met 261	-	initiating methionine
Gly 262	-	expression tag
Ser 263	-	expression tag
Ser 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
Leu 273	-	expression tag
Glu 274	-	expression tag
Val 275	-	expression tag
Leu 276	-	expression tag
Phe 277	-	expression tag
Gln 278	-	expression tag
Gly 279	-	expression tag
Pro 280	-	expression tag
His 281	-	expression tag
Met 282	-	expression tag
Met 283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	85370.5
Non-Polymers*	Number of molecules	8
	Total formula weight	968.7
All*	Total formula weight	86339.3

*Water molecules are not included.