PDB: 1588 resultsInfo pagesStatus searchChemie searchBIRD

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4U15	M3-mT4L receptor bound to tiotropium Descriptor: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, D(-)-TARTARIC ACID, ... Authors: Thorsen, T.S, Matt, R, Weis, W.I, Kobilka, B. Deposit date: 2014-07-15 Release date: 2014-11-26 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure, 22, 2014
1QS3	NMR SOLUTION CONFORMATION OF AN ANTITOXIC ANALOG OF ALPHA-CONOTOXIN GI Descriptor: DES-GLU1-[CYS3ALA]-DES-CYS13-ALPHA CONOTOXIN GI Authors: Mok, K.H, Han, K.-H. Deposit date: 1999-06-25 Release date: 1999-10-06 Last modified: 2014-03-12 Method: SOLUTION NMR Cite: NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins. Biochemistry, 38, 1999
8CAU	human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. Deposit date: 2023-01-24 Release date: 2023-10-11 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
6USF	CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... Authors: Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. Deposit date: 2019-10-26 Release date: 2020-04-29 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.87 Å) Cite: Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
4B5D	Capitella teleta AChBP in complex with psychonicline (3-((2(S)- Azetidinyl)methoxy)-5-((1S,2R)-2-(2-hydroxyethyl)cyclopropyl)pyridine) Descriptor: 2-[(1R,2S)-2-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]cyclopropyl]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Nys, M, Ulens, C. Deposit date: 2012-08-03 Release date: 2012-09-26 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.195 Å) Cite: Insights Into the Structural Determinants Required for High- Affinity Binding of Chiral Cyclopropane-Containing Ligands to Alpha4Beta2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic Ligands. J.Med.Chem., 55, 2012
6ZSS	NMR structure of water-soluble domain of human Lynx2 (Lypd1) protein Descriptor: Ly6/PLAUR domain-containing protein 1 Authors: Kocharovskaya, M.V, Paramonov, A.S, Lyukmanova, E.N, Shenkarev, Z.O. Deposit date: 2020-07-16 Release date: 2021-01-13 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors. Int J Mol Sci, 21, 2020
1HC9	alpha-bungarotoxin complexed with high affinity peptide Descriptor: ALPHA-BUNGAROTOXIN ISOFORM A31, ALPHA-BUNGAROTOXIN ISOFORM V31, IODIDE ION, ... Authors: Harel, M, Kasher, R, Sussman, J.L. Deposit date: 2001-05-02 Release date: 2001-11-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between Alpha-Bungarotoxin and a Mimotope Peptide. Neuron, 32, 2001
6OVJ	NMR structure of truncated alpha conotoxin SII: Ile-SII(3-14) Descriptor: Alpha-conotoxin S2 Authors: Chin, Y.K.-Y, Wilhelm, P, Alewood, P.F. Deposit date: 2019-05-08 Release date: 2020-05-06 Last modified: 2023-10-11 Method: SOLUTION NMR Cite: Cysteine-Rich alpha-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. Acs Chem Neurosci, 13, 2022
2ABX	THE CRYSTAL STRUCTURE OF ALPHA-BUNGAROTOXIN AT 2.5 ANGSTROMS RESOLUTION. RELATION TO SOLUTION STRUCTURE AND BINDING TO ACETYLCHOLINE RECEPTOR Descriptor: ALPHA-BUNGAROTOXIN Authors: Love, R, Stroud, R. Deposit date: 1986-02-19 Release date: 1986-05-07 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng., 1, 1986
1PEN	ALPHA-CONOTOXIN PNI1 Descriptor: ALPHA-CONOTOXIN PNIA Authors: Hu, S.-H, Gehrmann, J, Guddat, L.W, Alewood, P.F, Craik, D.J, Martin, J.L. Deposit date: 1996-01-29 Release date: 1997-04-21 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus. Structure, 4, 1996
2XYS	Crystal structure of Aplysia californica AChBP in complex with strychnine Descriptor: SOLUBLE ACETYLCHOLINE RECEPTOR, STRYCHNINE Authors: Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. Deposit date: 2010-11-19 Release date: 2011-03-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.909 Å) Cite: A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors. Plos Biol., 9, 2011
2XYT	Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine Descriptor: D-TUBOCURARINE, SOLUBLE ACETYLCHOLINE RECEPTOR Authors: Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. Deposit date: 2010-11-19 Release date: 2011-03-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors. Plos Biol., 9, 2011
2Y58	Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 6) Descriptor: CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... Authors: Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. Deposit date: 2011-01-12 Release date: 2011-06-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
2Y54	Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Fragment 1) Descriptor: CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... Authors: Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. Deposit date: 2011-01-12 Release date: 2011-06-15 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
2Y56	Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 3) Descriptor: CHLORIDE ION, GLYCEROL, SOLUBLE ACETYLCHOLINE RECEPTOR, ... Authors: Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. Deposit date: 2011-01-12 Release date: 2011-06-15 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.59 Å) Cite: Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
2Y57	Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 4) Descriptor: CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... Authors: Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. Deposit date: 2011-01-12 Release date: 2011-06-15 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
7N21	NMR structure of AnIB-OH Descriptor: Alpha-conotoxin AnIB Authors: Conibear, A.C, Rosengren, K.J, Lee, H.S. Deposit date: 2021-05-28 Release date: 2021-11-17 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
7N22	NMR structure of AnIB[Y(SO3)16Y]-NH2 Descriptor: Alpha-conotoxin AnIB Authors: Conibear, A.C, Rosengren, K.J, Lee, H.S. Deposit date: 2021-05-28 Release date: 2021-11-17 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
7N23	NMR structure of AnIB[Y(SO3)16Y]-OH Descriptor: Alpha-conotoxin AnIB Authors: Conibear, A.C, Rosengren, K.J, Lee, H.S. Deposit date: 2021-05-28 Release date: 2021-11-10 Last modified: 2024-10-23 Method: SOLUTION NMR Cite: Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
7N20	NMR structure of native AnIB Descriptor: Alpha-conotoxin AnIB Authors: Conibear, A.C, Rosengren, K.J, Lee, H.S. Deposit date: 2021-05-28 Release date: 2021-11-17 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
7N1Z	NMR structure of native PnIA Descriptor: Alpha-conotoxin PnIA Authors: Conibear, A.C, Rosengren, K.J, Lee, H.S. Deposit date: 2021-05-28 Release date: 2021-11-17 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
8CE4	Human alpha7 nicotinic receptor in complex with the E3 nanobody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody E3, ... Authors: Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. Deposit date: 2023-02-01 Release date: 2023-10-11 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
8CI1	Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. Deposit date: 2023-02-08 Release date: 2023-10-11 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
8CI2	human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody C4, ... Authors: Prevost, M.S, Barilone, N, Dejean de la Batie, G, Pons, S, Ayme, G, England, P, Gielen, M, Bontems, F, Pehau-Arnaudet, G, Maskos, U, Lafaye, P, Corringer, P.-J. Deposit date: 2023-02-08 Release date: 2023-10-11 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14, 2023
2XZ6	MTSET-modified Y53C mutant of Aplysia AChBP Descriptor: 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, SOLUBLE ACETYLCHOLINE RECEPTOR Authors: Brams, M, Gay, E.A, Colon Saez, J, Guskov, A, Van Elk, R, Van Der Schors, R.C, Peigneur, S, Tytgat, J, Strelkov, S.V, Smit, A.B, Yakel, J.L, Ulens, C. Deposit date: 2010-11-23 Release date: 2010-12-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.137 Å) Cite: Crystal Structures of a Cysteine-Modified Mutant in Loop D of Acetylcholine Binding Protein J.Biol.Chem., 286, 2011

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