8CI2

human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions

Summary for 8CI2

Entry DOI	10.2210/pdb8ci2/pdb
EMDB information	16666
Descriptor	Neuronal acetylcholine receptor subunit alpha-7, Nanobody C4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	ion channel nanobody nicotinic acetylcholine receptor, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	272068.02
Authors	Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.-J. (deposition date: 2023-02-08, release date: 2023-10-11)
Primary citation	Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.J. An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14:5964-5964, 2023 Cited by PubMed: 37749098 DOI: 10.1038/s41467-023-41734-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation