8CI2

human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC

Chain	Residue	Details
A	CYS127-CYS141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	425
Details	TRANSMEM: Helical => ECO:0000269|PubMed:33735609, ECO:0007744|PDB:7KOO

Chain	Residue	Details
A	GLY211-LEU231
C	GLY236-VAL256
C	LEU269-LEU292
C	VAL340-SER362
D	GLY211-LEU231
D	GLY236-VAL256
D	LEU269-LEU292
D	VAL340-SER362
E	GLY211-LEU231
E	GLY236-VAL256
E	LEU269-LEU292
A	GLY236-VAL256
E	VAL340-SER362
A	LEU269-LEU292
A	VAL340-SER362
B	GLY211-LEU231
B	GLY236-VAL256
B	LEU269-LEU292
B	VAL340-SER362
C	GLY211-LEU231

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D

Chain	Residue	Details
A	ARG19
B	ARG19
C	ARG19
D	ARG19
E	ARG19

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D

Chain	Residue	Details
A	VAL21
B	VAL21
C	VAL21
D	VAL21
E	VAL21

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site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8C, ECO:0007744|PDB:8V8D

Chain	Residue	Details
A	SER149
B	SER149
C	SER149
D	SER149
E	SER149

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site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8V8D

Chain	Residue	Details
A	TYR187
B	TYR187
C	TYR187
D	TYR187
E	TYR187

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site_id	SWS_FT_FI6
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN23
D	ASN23
D	ASN67
D	ASN110
E	ASN23
E	ASN67
E	ASN110
A	ASN67
A	ASN110
B	ASN23
B	ASN67
B	ASN110
C	ASN23
C	ASN67
C	ASN110

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