2Y58

Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 6)

Summary for 2Y58

Related2WN9 2W8F 2XZ6 2BYP 2C9T 2XYT 2BYQ 2W8G 2X00 2UZ6 2WNL 2BR7 2BR8 2XYS 2XNV 2BYR 2XZ5 2BYS 2Y54 2BYN 2XNT 2W8E 2WNJ 2WZY 2WNC 2XNU 2Y57 2Y56
DescriptorSOLUBLE ACETYLCHOLINE RECEPTOR, [(1R,5S)-8-[(2R)-2-HYDROXY-2-PHENYL-ETHYL]-8-METHYL-8-AZONIABICYCLO[3.2.1]OCTAN-3-YL] BENZOATE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsreceptor
Biological sourceAPLYSIA CALIFORNICA (CALIFORNIA SEA HARE)
Total number of polymer chains5
Total molecular weight125872.23
Authors
Rucktooa, P.,Edink, E.,deEsch, I.J.P.,Sixma, T.K. (deposition date: 2011-01-12, release date: 2011-06-15, Last modification date: 2019-04-24)
Primary citation
Edink, E.,Rucktooa, P.,Retra, K.,Akdemir, A.,Nahar, T.,Zuiderveld, O.,Van Elk, R.,Janssen, E.,Van Nierop, P.,Van Muijlwijk-Koezen, J.,Smit, A.B.,Sixma, T.K.,Leurs, R.,De Esch, I.J.P.
Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis.
J.Am.Chem.Soc., 133:5363-, 2011
PubMed: 21322593 (PDB entries with the same primary citation)
DOI: 10.1021/JA110571R
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20950 6.9% 2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution