2Y58

Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 6)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE V38 A 301

Chain	Residue
A	TYR91
B	ILE116
A	TRP145
A	TYR186
A	CYS188
A	CYS189
A	TYR193
B	GLN36
B	TYR53
B	MET114

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
B	LYS40

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	TYR167
A	SER169
E	CYS125
E	ASP126

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	PRO102
A	GLN103

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE V38 B 301

Chain	Residue
B	TYR91
B	TRP145
B	TYR186
B	CYS188
B	CYS189
B	TYR193
C	GLN36
C	TYR53
C	MET114
C	ILE116
C	SER165

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 501

Chain	Residue
C	LYS40

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 502

Chain	Residue
B	TYR167
B	SER169

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 601

Chain	Residue
B	VAL183
B	HIS185
C	ASP126
D	TYR167
D	SER169

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE V38 C 301

Chain	Residue
C	TYR91
C	TRP145
C	TYR186
C	CYS188
C	TYR193
D	GLN36
D	TYR53

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 501

Chain	Residue
D	LYS40

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE V38 D 301

Chain	Residue
D	TYR91
D	TRP145
D	CYS188
D	CYS189
D	TYR193
E	GLN36
E	TYR53
E	MET114
E	ILE116

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE V38 E 301

Chain	Residue
A	GLN36
A	TYR53
A	MET114
E	TYR91
E	TRP145
E	TYR186
E	CYS188
E	TYR193

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 501

Chain	Residue
A	LYS40

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 601

Chain	Residue
E	LYS141
E	GLN182
E	GLN184
E	ASN197

---