8H78
| Crystal structure of human MMP-2 catalytic domain in complex with inhibitor | Descriptor: | (2~{R})-2-[[4-[(4-aminocarbonylphenyl)carbonylamino]phenyl]sulfonylamino]-5-[(2~{S},4~{S})-4-azanyl-2-[[(2~{S})-1-[[(2~{S})-1-[(5-azanyl-5-oxidanylidene-pentyl)amino]-5-oxidanyl-1,5-bis(oxidanylidene)pentan-2-yl]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxidanylidene-pentanoic acid, CALCIUM ION, DIHYDROGENPHOSPHATE ION, ... | Authors: | Kamitani, M, Takeuchi, T, Mima, M. | Deposit date: | 2022-10-19 | Release date: | 2023-01-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. J.Med.Chem., 66, 2023
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7XJO
| Crystal structure of human MMP-2 catalytic domain in complex with inhibitor | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kamitani, M, Mima, M, Takeuchi, T. | Deposit date: | 2022-04-18 | Release date: | 2022-06-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J.Med.Chem., 65, 2022
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7XGJ
| Crystal structure of human MMP-2 catalytic domain in complex with inhibitor | Descriptor: | CALCIUM ION, GZS-ASN-ASP-ALA-LEU-IML-EOE-NH2, Matrix metalloproteinase-2, ... | Authors: | Kamitani, M, Mima, M, Takeuchi, T. | Deposit date: | 2022-04-05 | Release date: | 2022-06-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J.Med.Chem., 65, 2022
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3AYU
| Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor | Descriptor: | 72 kDa type IV collagenase, Amyloid beta A4 protein, CALCIUM ION, ... | Authors: | Hashimoto, H, Takeuchi, T, Komatsu, K, Miyazaki, K, Sato, M, Higashi, S. | Deposit date: | 2011-05-17 | Release date: | 2011-08-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor J.Biol.Chem., 2011
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1HOV
| SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 | Descriptor: | CALCIUM ION, MATRIX METALLOPROTEINASE-2, N-{4-[(1-HYDROXYCARBAMOYL-2-METHYL-PROPYL)-(2-MORPHOLIN-4-YL-ETHYL)-SULFAMOYL]-4-PENTYL-BENZAMIDE, ... | Authors: | Feng, Y, Likos, J.J, Zhu, L, Woodward, H, Munie, G, McDonald, J.J, Stevens, A.M, Howard, C.P, De Crescenzo, G.A, Welsch, D, Shieh, H.-S, Stallings, W.C. | Deposit date: | 2000-12-11 | Release date: | 2001-12-12 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor Biochim.Biophys.Acta, 1598, 2002
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1KS0
| The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | Descriptor: | Matrix Metalloproteinase 2 | Authors: | Gehrmann, M, Briknarova, K, Banyai, L, Patthy, L, Llinas, M. | Deposit date: | 2002-01-10 | Release date: | 2002-02-20 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains. Biol.Chem., 383, 2002
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1EAK
| Catalytic domain of proMMP-2 E404Q mutant | Descriptor: | 72 KDA TYPE IV COLLAGENASE, CALCIUM ION, INHIBITOR PEPTIDE, ... | Authors: | Bergmann, U, Tuuttila, A, Tryggvason, K, Morgunova, E. | Deposit date: | 2001-07-12 | Release date: | 2002-08-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Crystal Structure of Human Mmp-2 Reveals a New P To be Published
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1QIB
| CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN | Descriptor: | 72 kDa type IV collagenase, CALCIUM ION, ZINC ION | Authors: | Dhanaraj, V, Williams, M.G, Ye, Q.-Z, Molina, F, Johnson, L.L, Ortwine, D.F, Pavlovsky, A, Rubin, J.R, Skeean, R.W, White, A.D, Humblet, C, Hupe, D.J, Blundell, T.L. | Deposit date: | 1999-06-11 | Release date: | 1999-11-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray structure of gelatinase A catalytic domain complexed with a hydroxamate inhibitor Croatica Chemica Acta, 72, 1999
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1RTG
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1CK7
| GELATINASE A (FULL-LENGTH) | Descriptor: | CALCIUM ION, CHLORIDE ION, PROTEIN (GELATINASE A), ... | Authors: | Morgunova, E, Tuuttila, A, Bergmann, U, Isupov, M, Lindqvist, Y, Schneider, G, Tryggvason, K. | Deposit date: | 1999-04-28 | Release date: | 1999-08-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science, 284, 1999
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1CXW
| THE SECOND TYPE II MODULE FROM HUMAN MATRIX METALLOPROTEINASE 2 | Descriptor: | HUMAN MATRIX METALLOPROTEINASE 2 | Authors: | Briknarova, K, Grishaev, A, Banyai, L, Tordai, H, Patthy, L, Llinas, M. | Deposit date: | 1999-08-31 | Release date: | 1999-11-12 | Last modified: | 2022-12-21 | Method: | SOLUTION NMR | Cite: | The second type II module from human matrix metalloproteinase 2: structure, function and dynamics. Structure Fold.Des., 7, 1999
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1GEN
| C-TERMINAL DOMAIN OF GELATINASE A | Descriptor: | CALCIUM ION, CHLORIDE ION, GELATINASE A, ... | Authors: | Libson, A.M, Gittis, A.G, Collier, I.E, Marmer, B.L, Goldberg, G.G, Lattman, E.E. | Deposit date: | 1995-07-19 | Release date: | 1996-08-17 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of the haemopexin-like C-terminal domain of gelatinase A. Nat.Struct.Biol., 2, 1995
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1GXD
| proMMP-2/TIMP-2 complex | Descriptor: | 72 KDA TYPE IV COLLAGENASE, CALCIUM ION, METALLOPROTEINASE INHIBITOR 2, ... | Authors: | Morgunova, E, Tuuttila, A, Bergmann, U, Tryggvason, K. | Deposit date: | 2002-04-02 | Release date: | 2002-07-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Insight Into the Complex Formation of Latent Matrix Metalloproteinase 2 with Tissue Inhibitor of Metalloproteinase 2 Proc.Natl.Acad.Sci.USA, 99, 2002
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1J7M
| The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | Descriptor: | MATRIX METALLOPROTEINASE 2 | Authors: | Briknarova, K, Gehrmann, M, Banyai, L, Tordai, H, Patthy, L, Llinas, M. | Deposit date: | 2001-05-17 | Release date: | 2001-05-30 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct. J.Biol.Chem., 276, 2001
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