1HOV

SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020

Summary for 1HOV

DescriptorMATRIX METALLOPROTEINASE-2, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywordsenzyme-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix P08253
Total number of polymer chains1
Total molecular weight19277.1
Authors
Feng, Y.,Likos, J.J.,Zhu, L.,Woodward, H.,Munie, G.,McDonald, J.J.,Stevens, A.M.,Howard, C.P.,De Crescenzo, G.A.,Welsch, D.,Shieh, H.-S.,Stallings, W.C. (deposition date: 2000-12-11, release date: 2001-12-12, Last modification date: 2011-07-13)
Primary citation
Feng, Y.,Likos, J.J.,Zhu, L.,Woodward, H.,Munie, G.,McDonald, J.J.,Stevens, A.M.,Howard, C.P.,De Crescenzo, G.A.,Welsch, D.,Shieh, H.-S.,Stallings, W.C.
Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor
Biochim.Biophys.Acta, 1598:10-23, 2002
PubMed: 12147339 (PDB entries with the same primary citation)
DOI: 10.1016/S0167-4838(02)00307-2
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers6211.2%33.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures