1QIB

CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN

Summary for 1QIB

• Entry DOI: 10.2210/pdb1qib/pdb
• Descriptor: 72 kDa type IV collagenase, ZINC ION, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, matrixin, matrix metalloproteinase-2 (mmp-2), gelatinase a, metzincin, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Cytoplasm: P08253
• Total number of polymer chains: 1
• Total formula weight: 18208.91

Authors

Dhanaraj, V.,Williams, M.G.,Ye, Q.-Z.,Molina, F.,Johnson, L.L.,Ortwine, D.F.,Pavlovsky, A.,Rubin, J.R.,Skeean, R.W.,White, A.D.,Humblet, C.,Hupe, D.J.,Blundell, T.L. (deposition date: 1999-06-11, release date: 1999-11-19, Last modification date: 2023-12-27)

• Primary citation: Dhanaraj, V.,Williams, M.G.,Ye, Q.-Z.,Molina, F.,Johnson, L.L.,Ortwine, D.F.,Pavlovsky, A.,Rubin, J.R.,Skeean, R.W.,White, A.D.,Humblet, C.,Hupe, D.J.,Blundell, T.L.; X-ray structure of gelatinase A catalytic domain complexed with a hydroxamate inhibitor; Croatica Chemica Acta, 72:575-591, 1999

Experimental method

X-RAY DIFFRACTION (2.8 Å)