7XJO

Crystal structure of human MMP-2 catalytic domain in complex with inhibitor

Summary for 7XJO

Entry DOI	10.2210/pdb7xjo/pdb
Descriptor	Matrix metalloproteinase-2, RYH-KFB-GLU-ASP-DAB-LEU-EME-EOE-NH2, ZINC ION, ... (7 entities in total)
Functional Keywords	gelatinase a, matrix metalloproteinase-2, 72 kda type iv collagenase, hydrolase
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	40682.94
Authors	Kamitani, M.,Mima, M.,Takeuchi, T. (deposition date: 2022-04-18, release date: 2022-06-29, Last modification date: 2023-11-29)
Primary citation	Takeuchi, T.,Hayashi, M.,Tamita, T.,Nomura, Y.,Kojima, N.,Mitani, A.,Takeda, T.,Hitaka, K.,Kato, Y.,Kamitani, M.,Mima, M.,Toki, H.,Ohkubo, M.,Nozoe, A.,Kakinuma, H. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J.Med.Chem., 65:8493-8510, 2022 Cited by PubMed: 35687819 DOI: 10.1021/acs.jmedchem.2c00613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation